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    Male Polycystic Ovarian Syndrome Phenotype: A Meta-Analysis of Endocrine-Metabolic Dysregulation in Fathers and Brothers of PCOS-Affected Women

    November 2025 in “ Basic and Clinical Andrology ”
    Kyana Jafarabady, Ida Mohammadi, Shahryar Rajai Firouzabadi … Fahimeh Ramezani Tehrani
    Studysummary This systematic review and meta-analysis found that male first-degree relatives of women with PCOS have increased rates of metabolic issues, hormonal imbalances, and androgenic features compared to controls, suggesting a male equivalent of PCOS.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 12

    1. Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2023
    2. Male Polycystic Ovary Syndrome Equivalent Elsevier eBooks · 2023
    3. Maternal Androgen Excess Significantly Impairs Sexual Behavior in Male and Female Mouse Offspring: Perspective for a Biological Origin of Sexual Dysfunction in PCOS Frontiers in Endocrinology · 2023
    4. Male Equivalent Polycystic Ovarian Syndrome: Hormonal, Metabolic, and Clinical Aspects DOAJ (DOAJ: Directory of Open Access Journals) · 2020
    5. Increased DHEAS and Decreased Total Testosterone Serum Levels in a Subset of Men with Early-Onset Androgenetic Alopecia: Does a Male PCOS-Equivalent Exist? International Journal of Endocrinology · 2020
    6. Association of Type 2 Diabetes With Central-Scalp Hair Loss in a Large Cohort Study of African American Women International Journal of Women's Dermatology · 2019
    7. Does a Male Polycystic Ovarian Syndrome Equivalent Exist? Journal of Endocrinological Investigation · 2017
    8. A Comparison of the Hormonal Profile of Early Androgenetic Alopecia in Men With the Phenotypic Equivalent of Polycystic Ovarian Syndrome in Women JAMA Dermatology · 2016
    9. Metabolic and Reproductive Characteristics of First-Degree Relatives of Women with Self-Reported Oligo-Amenorrhea and Hirsutism Gynecological Endocrinology · 2010
    10. What May Be the Markers of the Male Equivalent of Polycystic Ovary Syndrome? Physiological Research · 2004
    11. Male Androgenetic Alopecia Clinical and Experimental Dermatology · 2002
    12. The Genetics of Androgenetic Alopecia Clinics in Dermatology · 2001