In this observational study, men with early onset androgenic alopecia exhibited a statistically significant correlation with more severe forms of coronary artery disease compared to those without the condition.
February 2016 in “PubMed” This review discusses testosterone replacement therapy, highlighting that most studies report no increased myocardial infarction risk when the therapy is properly administered with controlled hormone levels; it calls for careful consideration despite insurance coverage challenges.
January 2015 in “Side effects of drugs annual” This review discusses various sex hormones and related compounds, including estrogens and anabolic steroids, but reports no new findings; it highlights existing literature from 2014 regarding their use and effects.
November 2009 in “Cambridge University Press eBooks” This article notes that hair restoration surgery generally has a complication rate of less than 1%, but highlights rare instances of serious cardiovascular events.
February 2023 in “Clinical Toxicology” This letter to the editor raises concerns about minoxidil, an arterial vasodilator also used for androgenic alopecia, noting that overdose can cause severe side effects such as distributive shock, pulmonary edema, and myocardial ischemia.
June 2016 in “International journal of recent surgical and medical science” This study found that early-onset male androgenetic alopecia was associated with a higher prevalence of metabolic syndrome compared to age-matched controls.
1 citations
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January 2021 in “Menoufia Medical Journal” This study found that patients with alopecia areata had significantly higher troponin I levels compared to those with female pattern hair loss and healthy controls, suggesting an association with cardiovascular diseases.
52 citations
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August 2021 in “Microorganisms” This review observes higher ACE2 expression in myocardial and lung tissues of heart failure and COPD patients but finds no link between RAAS inhibitors and COVID-19 severity.
September 2025 in “Journal of Veterinary Cardiology” This study observed that a 13-month-old cat experienced transient myocardial thickening and congestive heart failure episodes likely due to minoxidil intoxication, coinciding with contact with a family member using the drug, suggesting environmental exposure may trigger cardiac events in pets.
44 citations
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March 2015 in “PLOS ONE” This study found that FGF-9 treatment in diabetic mice improved heart function after myocardial infarction by decreasing monocyte infiltration and promoting anti-inflammatory macrophage differentiation.
3 citations
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July 2024 in “Journal of Vascular Diseases” This review compiles existing research on ischemia-modified albumin (IMA) as a biomarker for myocardial ischemia, highlighting current gaps in understanding its formation and detection, with no new clinical results reported.
29 citations
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May 2016 in “Journal of the American Academy of Dermatology” This study observed that patients with alopecia areata had decreased odds of developing stroke and a potential decreased risk of acute myocardial infarction, though the latter was not statistically significant.
3 citations
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June 2022 in “e-Journal of Cardiovascular Medicine” This study found no significant difference in the ability of ischemia modified albumin and exercise electrocardiograms to determine myocardial ischemia in patients with stable angina pectoris.
3 citations
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December 2018 in “Biomedical and pharmacology journal/Biomedical & pharmacology journal” This study found that compound 3 derived from aza-bicyclo-carboxylic acid may exert a cardioprotective effect by reducing infarction area in myocardial ischemia-reperfusion injury, potentially involving A1-adenosine receptor activation and changes in cAMP levels.
January 2002 in “中国人民解放军军医大学学报:英文版” This study found that real-time 2-D Doppler echo of intracardiac blood flow helps evaluate myocardial infarction severity, with persistent late systolic inflow indicating worse left ventricular function.
13 citations
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July 2024 in “Circulation Research” In this review, researchers highlighted the pivotal role of the epicardium in heart regeneration and repair, particularly through its cellular programs and signaling during myocardial infarction, though they noted challenges in replicating these processes in nonregenerative mammals, suggesting pathways for innovative cardiovascular therapies.
13 citations
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November 2016 in “The Journal of urology/The journal of urology” In a population-based study, over 72,000 older men were examined, and dutasteride showed no increased risk of heart failure, myocardial infarction, or stroke compared to finasteride, as reported by the researchers.
13 citations
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March 1986 in “Clinical Cardiology” This case report describes a 31-year-old woman who developed transient heart failure during the acute phase of Kawasaki disease, highlighting that it can cause myocardial dysfunction in adults.
3 citations
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December 2020 in “Medical Journal of Cell Biology” This review summarizes advancements in stem cell technologies, highlighting their effectiveness in disease treatment and tissue reconstruction for conditions such as nerve palsy and myocardial infarction, supported by pre-clinical and clinical studies.
August 2025 in “Frontiers in Immunology” This meta-analysis found that patients with alopecia areata, particularly those with more extensive forms like alopecia totalis and universalis, may face a higher risk of cardiovascular disease, though no links were found with specific conditions like ischemic stroke or myocardial infarction.
January 2024 in “PloS one” This study found that rat hair-follicle-associated pluripotent stem cells can be successfully differentiated into beating atrial and ventricular cardiomyocytes by using specific combinations of growth factors and inhibitors in culture, demonstrating their potential to form functional myocardial fibers similar to adult heart cells.
September 2023 in “Frontiers in bioengineering and biotechnology” This review explores the role of JAG1 in disease treatment, highlighting the need for effective methods to deliver JAG1 in its bound form to activate NOTCH signaling for therapeutic applications in craniofacial bone loss and myocardial infarction.
January 2025 in “Exploratory Animal and Medical Research” Among adult male rats, this study found that combined exposure to lithium carbonate and lead acetate over 28 days led to synergistic cardiotoxic effects, evidenced by oxidative stress, ECG abnormalities, and molecular markers of increased apoptosis, despite no observable structural damage to myocardial tissue.
August 2016 in “PolyPublie (École Polytechnique de Montréal)” This study observed early cardiac effects in young minipigs following high-dose doxorubicin chemotherapy, with a decrease in heart function and changes in cardiac MRI measurements compared to controls.
November 2021 in “Circulation” This case report highlights the first known instance of ANA-negative systemic lupus erythematosus presenting as spontaneous coronary artery dissection, emphasizing a need for rheumatological evaluation in such patients.
52 citations
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March 1979 in “Toxicology and Applied Pharmacology” Minoxidil can cause heart muscle damage in dogs.
18 citations
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July 2015 in “Drug Healthcare and Patient Safety” This review discusses the benefits and cardiovascular risks of androgen deprivation therapy for prostate cancer patients, noting that optimizing cardiovascular risk factors is important when using ADT.
9 citations
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May 2014 in “Journal of Cardiovascular Development and Disease” This review discusses the role of Wnt signaling in cardiac development and explores attempts to modulate it for improving heart function after ischemic injury, but reports no new experimental results.
7 citations
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April 2025 in “Science Advances” This study suggests that a biomaterial-based approach using microneedles and ion solutions to deliver SiO3 2− ions may disrupt inflammatory cycles and improve outcomes in inflammatory dilated cardiomyopathy (iDCM).
5 citations
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May 2022 in “Lara D. Veeken” This study reports the first case of diverse medium-sized visceral arterial aneurysms in a patient with functionally impaired A20, potentially linked to HA20, and its atypical presentation in East Asia.