TLDR Dutasteride is as safe for the heart as finasteride.
In a population-based cohort study of 72,622 men aged 66 or older, researchers investigated the cardiovascular safety of dutasteride compared to finasteride. The study found no significant difference in the risk of heart failure, acute myocardial infarction, or stroke between patients treated with dutasteride and those treated with finasteride. The adjusted hazard ratios were 0.98 for heart failure, 0.94 for acute myocardial infarction, and 1.03 for stroke, indicating that dutasteride did not increase the risk of cardiovascular events relative to finasteride.
104 citations,
March 2014 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” DHT may increase the risk of heart disease and death in elderly men.
218 citations,
December 2011 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
235 citations,
September 2004 in “The Journal of urology/The journal of urology” Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.
184 citations,
January 2000 in “European Urology” Blocking the enzyme that turns testosterone into DHT can safely and effectively treat enlarged prostate.
June 2023 in “Clinica Chimica Acta” Finasteride and dutasteride effectively reduce DHT in hair, which may help evaluate their treatment success for hair loss.
January 2018 in “Surgical and Cosmetic Dermatology” 5-alpha reductase inhibitors like finasteride and dutasteride are effective for treating enlarged prostate and male pattern hair loss.
August 2016 in “Journal of Investigative Dermatology”
