155 citations
,
May 2016 in “Nature communications” This study found that mouse skin CD4(+) memory T cells are in equilibrium with the circulation under steady state but increase in specific clusters in response to infection or inflammation.
140 citations
,
March 2013 in “The journal of immunology/The Journal of immunology” This study found that IL-7 is crucial for the survival of memory regulatory T cells in the skin of mice, whereas IL-2 is essential for their initial generation but not for their maintenance.
25 citations
,
November 2020 in “Cell Reports Medicine” Developing human skin has immune cells with memory-like features.
21 citations
,
May 2016 in “Progress in Neuro-Psychopharmacology and Biological Psychiatry” Diazepam's effects on anxiety and memory differ between male and female rats due to hormonal influences.
21 citations
,
April 2008 in “Pediatric Research”
9 citations
,
March 2009 in “Psychoneuroendocrinology” This study found that variations in the androgen receptor gene influenced memory function in women, with GGN repeat polymorphisms significantly affecting logical memory performance only in females.
3 citations
,
January 2023 in “JEADV Clinical Practice” This study suggests that IL-17 may play a more significant role than IFN-γ in the pathogenesis of chronic alopecia areata, with increasing severity linked to Th17 lymphocytes and cytotoxic T lymphocyte infiltration.
June 2025 in “Frontiers in Neurology” This study found a significant association between finasteride use and increased risk of memory impairment, highlighting the need for risk communication and routine cognitive monitoring for long-term users.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that targeting skin-infiltrated memory phenotype T cells could offer a new therapeutic approach to manage lymphopenia-related diseases like graft-versus-host disease and immune reconstitution inflammatory syndrome.
April 2023 in “Journal of Investigative Dermatology” This research explored the roles of various T cell types in chronic alopecia areata, finding that increased severity of lesions and hair loss may be linked to decreased lesional Foxp3+ Tregs, with a notable role for IL-17 and Th17 lymphocytes in the pathological process.
September 2019 in “Journal of Investigative Dermatology” This study found that in chronic alopecia areata, increased IL-17 expression and CD8+CD49a-Trm cell infiltration in hair follicles were associated with more severe histopathologic gradings, while Foxp3+mTreg infiltration decreased.
245 citations
,
October 2015 in “Nature medicine” The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.
50 citations
,
May 2021 in “Frontiers in immunology” This review discusses how tissue resident memory T cells contribute to autoimmune skin diseases like vitiligo and psoriasis, highlighting their role in continuous immune activation, and reports no new clinical results.
22 citations
,
January 2017 in “Advanced Healthcare Materials” This study found that thermoresponsive hydrogels can maintain mechanical memory in fibroblasts, enhancing wound healing compared to traditional trypsinized methods.
9 citations
,
February 2025 in “Journal of Nanobiotechnology” In this study, researchers found that using bioinspired nanovesicles derived from inflammation memory-activated epidermal stem cells effectively promoted healing in diabetic wounds by reprogramming neutrophils to an anti-inflammatory phenotype in both laboratory and animal models.
In this study, researchers observed that during zebrafish fin regeneration, osteoblast Erk activity, influenced by Fgf receptor signaling, forms gradients scaling with amputation length, which predicts regenerative tissue growth and skeletal structure size.
5 citations
,
June 2010 in “Universitas Psychologica” This study found that progesterone implantation in castrated male rats mitigated stress-induced increases in corticosterone levels and protected against spatial memory impairment and increased exploratory behavior.
2 citations
,
May 2023 in “Frontiers in immunology” This review highlights advances in understanding inflammatory memory in epidermal stem cells, focusing on their capacity to remember prior inflammatory responses and respond more quickly to future stimuli, potentially aiding strategies against skin-related diseases.
1 citations
,
January 2018 in “Stem cell biology and regenerative medicine” This review discusses the roles of DNA methylation in skin development and regeneration, highlighting its impact on embryonic skin lineage, homeostasis, and potential therapeutic targets, but reports no new clinical results.
July 2025 in “Journal of Investigative Dermatology” Resident memory T cells and necroptosis may drive fibrosis in eosinophilic fasciitis and morphea.
July 2023 in “Nature Immunology” CD8+ virtual memory T cells may cause hair loss in alopecia areata.
November 2025 in “International Society of Hair Restoration Surgery” This obituary honors Dr. Grant Koher, a respected member of the ISHRS and a diplomate of the American Board of Hair Restoration Surgery, and reports no new research findings.
67 citations
,
January 2020 in “Cellular & Molecular Immunology/Cellular & molecular immunology” This review discusses the dual role of tissue-resident memory T cells in providing immune protection against infections and cancer and contributing to autoimmune skin disease pathology, without presenting new experimental results.
44 citations
,
February 2016 in “Science” Researchers developed a new type of memory using antiferromagnets that is stable, not disrupted by magnets, and works at room temperature.
2 citations
,
June 2025 in “Journal of Investigative Dermatology” CD8+ T cells re-expressing CD45RA may predict treatment resistance in severe alopecia areata.
2 citations
,
July 2017 in “Deleted Journal” This review discusses the memory enhancing activity of the ethanolic extract of Eclipta alba and reports no new clinical results.
July 2026 in “Frontiers in Immunology” This review highlights the role of epidermal tissue-resident memory T (T RM) cells in human skin, showing their involvement in immune surveillance and regulation within the epidermis, and suggesting their importance in understanding skin diseases like HIV infection and vitiligo.
January 2026 in “Experimental Dermatology” The study suggests that refractory chronic alopecia areata cases have more infiltrating skin resident memory T cells, and using a JAK inhibitor may be an effective treatment option.
November 2025 in “Journal of Investigative Dermatology” Chronic refractory alopecia areata has more skin-resident memory T cells, and JAK inhibitors may help reduce them.
April 2023 in “Journal of Investigative Dermatology” This study suggests that monitoring CD8+ TEMRA cells in patients with rapidly progressive alopecia areata treated with intravenous corticosteroids could help predict therapeutic outcomes.