Trastuzumab Induced Chemobrain, Atorvastatin Rescued Chemobrain with Enhanced Anticancer Effect and without Hair Loss Side Effect

    February 2019 in “ Journal of clinical medicine ”
    Seonhwa Lee, Hae June Lee, Hyunji Kang, Eun‐Ho Kim, Young‐Cheol Lim, Hyejin Park, Sang Moo Lim, Yong Jin Lee, Jung Min Kim, Jin Su Kim
    Image of study
    TLDR Atorvastatin reversed memory problems caused by cancer drug trastuzumab and improved its cancer-fighting abilities without causing hair loss.
    The study found that trastuzumab (TZB) therapy induced chemo-brain, characterized by decreased cerebral glucose metabolism and gray matter concentration in the frontal lobe, as evidenced by 18F-fluorodeoxyglucose Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) data. Atorvastatin (ATV) was able to reverse these effects and improve cognitive function, as confirmed by a passive avoidance test and quantitative real-time reverse transcription PCR. Additionally, ATV treatment resulted in a 100% increase in the penetration and accumulation of TZB in tumors, enhancing its anticancer efficacy. The study, which used an animal model with 150 μg TZB and five serial doses of 20 mg/kg ATV, also reported no hair loss side effects from ATV therapy.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community Hair Loss Results After 8 Months of Dutasteride

      in Progress Pictures  233 upvotes 1 month ago
      The user experienced increased hair density after 8 months of using dutasteride and 6 months of oral minoxidil. Some users joked about side effects, while others discussed the effectiveness of various treatments like finasteride and rosemary oil.

      community Hair Loss Due To Chlorine and Hard Metals In Water?

      in Research/Science  1 upvotes 2 months ago
      Hair loss possibly caused by chlorine and heavy metals in water was addressed by using a shower filter, ketoconazole shampoo, and PRP sessions, which stopped the hair loss but did not lead to regrowth. Other users suggested similar experiences and solutions, emphasizing the importance of a good water filter and patience for potential regrowth.

      community Hair Loss Treatments and Hair Transplant

      in Progress Pictures  4 upvotes 2 months ago
      The user is experiencing hair loss and is using oral finasteride, considering adding RU58841 and microneedling, and planning a hair transplant. They are seeking advice on whether to wait for treatment results or proceed with the transplant.

      community Hair loss steps, guide to beginners or anyone experiencing hair loss

      in Treatment  1 upvotes 2 months ago
      The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

      community Hair loss 30F - thoughts on red light therapy vs min/fin?

      in Female  6 upvotes 2 months ago
      The conversation discusses hair loss treatments for a 30-year-old female, comparing red light therapy with minoxidil and finasteride. Concerns about hormonal impact and potential pregnancy are raised, with suggestions to consider spironolactone and microneedling, while emphasizing the importance of consulting a dermatologist.

    Similar Research

    5 / 1000+ results