Bio-Analytical Method Development and Validation of Finasteride, Tadalafil, and Its Application to Pharmacokinetic Studies in Rat Plasma by Using LC-MS/MS

    September 2024 in “ International Journal of Applied Pharmaceutics ”
    Yesupadamu Rayinuthala, David Raju Medepalli, A. LAKSHMANARAO
    Studysummary This study describes a new LC-MS/MS method for analyzing Finasteride and Tadalafil, demonstrating system suitability, linearity, and accuracy in pharmacokinetic studies in rats, aligning with USFDA guidelines.
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    Research cited in this study 7

    1. Development of Validated Methods for the Simultaneous Quantification of Finasteride and Tadalafil in Newly Launched FDA-Approved Therapeutic Combination: Greenness Assessment Using AGP, Analytical Eco-Scale, and GAPI Tools RSC Advances · 2023
    2. Simultaneous Spectrophotometric Determination of Finasteride and Tadalafil in Recently FDA Approved Entadfi Capsules BMC chemistry · 2022
    3. Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review Current Medicinal Chemistry · 2019
    4. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    5. Selective and Rapid Determination of Tadalafil and Finasteride Using Solid Phase Extraction by High Performance Liquid Chromatography and Tandem Mass Spectrometry Journal of Pharmaceutical and Biomedical Analysis · 2018
    6. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    7. Female Pattern Hair Loss: A Clinical and Pathophysiological Review Anais Brasileiros De Dermatologia · 2015

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