Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review

December 2019 in “ Current Medicinal Chemistry ”

Homa Nomani, Amir Hooshang Mohammadpour, Seyed Adel Moallem, Mahdi Jannati Yazdanabad, George E. Barreto, Amirhossein Sahebkar

flutamide finasteride cyproterone acetate triptorelin anti-androgens Propecia

TLDR Anti-androgen drugs can help reduce OCD symptoms, but more large-scale trials are needed to confirm their effectiveness.

The systematic review investigated the effectiveness of anti-androgens in reducing Obsessive-Compulsive Disorder (OCD) symptoms. The study included one randomized and four non-randomized trials. The randomized trial showed that flutamide, an anti-androgen agent, was effective in reducing compulsion scores in male OCD patients with comorbid Tourette syndrome. Three out of four non-randomized trials showed that different anti-androgens including finasteride, cyproterone acetate, and triptorelin were effective in reducing OCD symptoms. However, the quality of evidence from these studies was considered low. The review concluded that more large randomized blinded clinical trials are needed to evaluate the effectiveness of anti-androgens in OCD patients, considering factors like gender, comorbidities, and subscales of Yale-Brown Obsessive-Compulsive Score (Y-BOCS).

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Research cited in this study

2 / 2 results

research A Preliminary Study of Finasteride in Tourette Syndrome

46 citations, September 2011 in “Movement Disorders”

Finasteride reduces Tourette syndrome symptoms, but results may be limited due to potential biases.

research Treatment of Tourette’s Syndrome With Finasteride

42 citations, December 2007 in “American Journal of Psychiatry”

Finasteride may effectively reduce Tourette's syndrome symptoms and improve life quality.

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research Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review

1 citations, December 2019 in “Current Medicinal Chemistry”

Anti-androgen drugs can help reduce OCD symptoms, but more large-scale trials are needed to confirm their effectiveness.