Anti-Androgen Drugs in the Treatment of Obsessive-Compulsive Disorder: A Systematic Review

    December 2019 in “ Current Medicinal Chemistry ”
    Homa Nomani, Amir Hooshang Mohammadpour, Seyed Adel Moallem, Mahdi Jannati Yazdanabad, George E. Barreto, Amirhossein Sahebkar
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    TLDR Anti-androgen drugs can help reduce OCD symptoms, but more large-scale trials are needed to confirm their effectiveness.
    The systematic review investigated the effectiveness of anti-androgens in reducing Obsessive-Compulsive Disorder (OCD) symptoms. The study included one randomized and four non-randomized trials. The randomized trial showed that flutamide, an anti-androgen agent, was effective in reducing compulsion scores in male OCD patients with comorbid Tourette syndrome. Three out of four non-randomized trials showed that different anti-androgens including finasteride, cyproterone acetate, and triptorelin were effective in reducing OCD symptoms. However, the quality of evidence from these studies was considered low. The review concluded that more large randomized blinded clinical trials are needed to evaluate the effectiveness of anti-androgens in OCD patients, considering factors like gender, comorbidities, and subscales of Yale-Brown Obsessive-Compulsive Score (Y-BOCS).
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