Finasteride Induces Cytoarchitectural Alterations in Hippocampus of Adult Male Wistar Rat: A Contributor to Neuropsychiatric Effects of Post-Finasteride Syndrome

The study investigated the effects of finasteride on the hippocampus of young adult male albino rats by administering different doses (0.5 mg/kg, 1 mg/kg, and 2 mg/kg) for 14 days. The results showed a 10% reduction in the thickness of the CA1 layer of the hippocampus in finasteride-treated groups, with average thicknesses between 69.10 μm and 70.21 μm compared to 78.01 μm in the control group. These atrophic changes in the CA1 subfield suggest a potential basis for the memory impairments observed in Post-Finasteride Syndrome.