Finasteride Induces Cytoarchitectural Alterations in Hippocampus of Adult Male Wistar Rat: A Contributor to Neuropsychiatric Effects of Post-Finasteride Syndrome

May 2024

Churchill Ihentuge, Hope Okechukwu, Ambrose Obialor

finasteride hippocampus CA1 layer Post-Finasteride Syndrome Propecia

TLDR Finasteride may cause memory problems by damaging the hippocampus.

The study investigated the effects of finasteride on the hippocampus of young adult male albino rats by administering different doses (0.5 mg/kg, 1 mg/kg, and 2 mg/kg) for 14 days. The results showed a 10% reduction in the thickness of the CA1 layer of the hippocampus in finasteride-treated groups, with average thicknesses between 69.10 μm and 70.21 μm compared to 78.01 μm in the control group. These atrophic changes in the CA1 subfield suggest a potential basis for the memory impairments observed in Post-Finasteride Syndrome.

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