96 citations,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” The document concludes that adult mammalian skin contains multiple stem cell populations with specific markers, important for understanding skin regeneration and related conditions.
26 citations,
August 1971 in “Journal of Morphology” Lizards can regrow their tail scales with the same structure, distribution, and gender-specific features as the original ones, and this unique ability is not seen in adult mammals.
1 citations,
November 2017 The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.
October 2021 in “Journal of Investigative Dermatology” DPP4, a molecule in skin, helps heal large wounds and regrow hair follicles when its levels are reduced.
January 2006 in “Elsevier eBooks” Most vertebrates can regenerate skin, nails, and corneas, but only some can regenerate teeth and lenses.
13 citations,
January 2020 in “Scientific Reports” The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.
182 citations,
August 2016 in “Development” ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.
120 citations,
November 2014 in “Biological Reviews” The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.
118 citations,
January 2016 in “Current Topics in Developmental Biology” The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.
4 citations,
July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” BLMP-1 is important for regular molting and gene expression cycles in worms.
1 citations,
October 2013 Different ectodermal organs like hair and feathers regenerate differently, with specific stem cells and signals involved in their growth and response to the environment.
34 citations,
January 2013 in “Frontiers in genetics” Stem cells can help other stem cells by producing supportive factors.
19 citations,
December 2018 in “Experimental and Molecular Medicine” Small molecule IM boosts hair growth by changing stem cell metabolism.
August 2024 in “Life Science Alliance” Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.
May 2024 in “Scientific reports” Twist2 is essential for scarless skin healing and hair growth in mouse fetuses.
March 2024 in “Research Square (Research Square)” Twist2 is essential for proper skin healing and hair growth in developing mice.
829 citations,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
305 citations,
June 2012 in “Nature” Hair regeneration needs dynamic cell behavior and mesenchyme presence for stem cell activation.
295 citations,
June 2009 in “Science” Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.
160 citations,
April 2012 in “Journal of Cellular and Molecular Medicine” Telocytes might help with skin repair and regeneration.
149 citations,
July 2014 in “Cold Spring Harbor Perspectives in Medicine” The dermal papilla is crucial for hair growth and health, and understanding it could lead to new hair loss treatments.
25 citations,
June 2021 in “Developmental Cell” Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.
24 citations,
January 2019 in “Science China Life Sciences” Chitosan/LiCl composite scaffolds help heal deep skin wounds better.
17 citations,
December 2010 in “Journal of Investigative Dermatology” Flightless I protein affects hair growth, with low levels delaying it and high levels increasing hair length in rodents.
13 citations,
December 2014 in “Stem Cells” Hair and skin can regenerate without bulge stem cells due to other compensating cells.
December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” MicroRNA-205 helps hair grow by changing the stiffness and contraction of hair follicle cells.
March 2020 in “Central European Journal of Biology” The study found that stem cells and neutrophils are important for regenerating hair follicle structures in mice.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” Certain small molecules can help regrow hair by turning on the body's cell cleanup process.
408 citations,
January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
232 citations,
October 2015 in “International journal of molecular sciences” Stem cells are crucial for skin repair and new treatments for chronic wounds.