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March 2022 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that HIF-P4H-2 function in FoxD1-lineage cells is crucial for normal hair follicle development and homeostasis in mice, implicating disrupted HIF, TGF-β, and Notch signaling pathways in associated defects.
July 2026 in “Veterinary Sciences” This study explored the decline in cashmere production in Inner Mongolian cashmere goats through RNA-seq analysis, finding that AKT1 expression and related signaling pathways are age-dependent, with peak AKT1 upregulation at 12 months aligning with peak cashmere production.
July 2026 in “International Journal For Multidisciplinary Research” In this study, researchers found that EqualsTwo Oil Free Hair Oil significantly reduced hair fall by up to 73.8% and improved hair strength, scalp condition, and growth cycle parameters in pregnant and lactating women over a 30-day period, without adverse effects.
June 2026 in “Research Square” This study identified a group of dermal fibroblasts near hair follicle stem cells in mice that facilitate hair regeneration by creating a biomechanically compliant extracellular matrix, enhancing stem cell activation and promoting a positive feedback loop for tissue regeneration.
February 2026 in “The Animal Biology” In this animal study, Hirudo verbana leech extract significantly improved hair follicle regeneration and accelerated wound healing in rats, demonstrating potential as a safe and effective agent for skin repair due to its bioactive compounds with regenerative and anti-inflammatory properties.
June 2025 in “International Journal of Research in Dermatology” In this case series, researchers observed that combining 0.1% tretinoin gel with 5% minoxidil over 90 days improved hair growth and patient satisfaction in androgenetic alopecia patients who did not previously respond to minoxidil alone, with significant increases in hair count, density, and quality.
May 2025 in “Research Journal of Biotechnology” This study found that diabetic individuals experienced significant changes in hair characteristics, including reduced thickness, strength, and altered growth cycle phases, correlated with poor glycaemic control and haematological variations compared to healthy controls.
January 2025 in “Arquivo Brasileiro de Medicina Veterinária e Zootecnia” In this study, researchers observed that telogen hair was more prevalent than anagen hair in both male and female agoutis over a one-year period in Teresina-PI, regardless of dry or rainy seasons, with no significant differences in dermal follicular volume between the sexes.
July 2024 in “Journal of Cosmetic Dermatology” This study on rats found that topical application of bacterial melanin significantly stimulates hair growth by prolonging the anagen phase and enhancing vasodilation in the treated skin areas compared to controls, suggesting its potential as a cost-effective hair growth treatment.
December 2023 in “Annals of phytomedicine” This study reports that dutasteride, used alone or with tamsulosin, effectively reduces acute urine retention and surgery risk in men with benign prostatic hyperplasia, and may lower prostate cancer incidence, suggesting potential chemopreventive benefits.
November 2023 in “PubMed” In this study using animal models, umbilical cord stem cell conditioned media combined with oral anti-androgens improved hair regeneration in androgenetic alopecia, enhancing hair follicle cycles and reducing inflammation, suggesting potential as a promising therapy.
This study found that among military personnel treated for respiratory diseases, an accelerated transition to telogen hair loss was associated with lower hemoglobin levels.
March 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that the absence of Hif-p4h-2 in specific mouse skin cells disrupted hair follicle development, leading to hair loss due to irregular keratin formation and pathway signaling.
January 2011 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” This study found that a combination of spermidin, rutine, and zeaxantine effectively reduced staurosporin-induced apoptosis in cultured hair follicle dermal papilla cells, potentially preventing the regression phase in the hair follicle cycle.
November 2025 in “Journal of Investigative Dermatology” Estetrol may help prevent hair loss and support hair growth in women.
September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, researchers developed non-invasive methods to monitor hair shaft, melanin, and collagen dynamics in C57BL/6 mice across different hair follicle cycle phases, supporting non-invasive research in hair loss treatment development.
November 2024 in “Journal of Investigative Dermatology” Aptamers can improve wound healing and promote hair growth.
July 2024 in “Journal of Investigative Dermatology” Ashwagandha nanoparticles help hair grow by increasing a growth factor.
April 2023 in “Journal of Investigative Dermatology” This study examined Ashwagandha-derived exosome-like nanoparticles and found that they increased hair growth markers and hair shaft production in human hair follicles ex vivo, suggesting potential for plant-derived exosome therapies in hair loss treatments.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the natural estrogen Estetrol (E4) may promote hair follicle growth and prevent miniaturization, suggesting its potential as a treatment for hair loss disorders.
November 2022 in “Journal of Investigative Dermatology” This study found that marine-derived collagen peptides slightly promoted hair matrix proliferation and prolonged hair growth phase in human hair follicles ex vivo, suggesting potential benefits for hair loss treatment.
November 2022 in “Journal of Investigative Dermatology” This study found that stimulating the olfactory receptor OR2A4/7 with cyclohexyl salicylate promoted human hair growth and increased progeny of hair follicle epithelial stem cells in an ex vivo setting.
November 2022 in “Journal of Investigative Dermatology” This study found that human scalp hair follicles produce neurohormones and responded to GHRH stimulation by prolonging hair growth, suggesting a functional peripheral HPS neuroendocrine signaling axis in the skin.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observes that TYK2 inhibition with BMS-986202 may extend hair follicle growth phases and decrease inflammatory cell markers in alopecia areata, suggesting potential for clinical application.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, mouse sebaceous glands were found to require nerves for growth during active hair cycles, suggesting a nerve-dependent sebaceous gland cycle coordinated with hair growth.
April 2019 in “Journal of Investigative Dermatology” This study reported that a Maca hydrolysate extract protected human hair follicles from oxidative and inflammatory stress and promoted hair growth in ex vivo models, suggesting a potential use for managing hair loss.
This study found that hair germ and epidermal basal cells differ in keratin expressions in rat hair tissues, with hair-specific keratins appearing after the differentiation of each layer.
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October 2011 in “Development” This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.
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October 2025 in “Nature Communications” This study observed that, in mouse ear epidermal stem cells, a cell-autonomous size control mechanism involving the RB pathway dictates S phase entry timing based on cell size, despite external environmental variations affecting growth rates.
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August 1994 in “Journal of Cutaneous Pathology” This study found that matrix cells from normal hair follicles primarily had a 2C DNA content, while those in androgenetic alopecia showed a significant increase in cells with a higher DNA content.