Novel Effect of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on Hair Follicle Cells Proliferation and Hair Growth

August 2023 in “ Biomolecules & therapeutics ”

Hae Chan Ha, Dan Zhou, Zhicheng Fu, Moon Jung Back, Ji Min Jang, In Chul Shin, Dae Kyong Kim

Hyaluronan Proteoglycan Link Protein 1 HAPLN1 hair follicle cells hair growth anagen phase human hair matrix cells recombinant human HAPLN1 rhHAPLN1 TGF-B receptor II ERK1/2 signaling pathway

Studysummary In this study, researchers found that recombinant human HAPLN1 promoted hair growth in mice and human hair matrix cells by activating specific signaling pathways, suggesting it may offer a potential hair loss treatment with fewer side effects than existing medications. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigates the effects of Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1) on hair follicle cell proliferation and hair growth, using male C57BL/6 mice. HAPLN1 was found to be predominantly expressed during the anagen phase and promoted the proliferation of human hair matrix cells. Treatment with recombinant human HAPLN1 (rhHAPLN1) increased levels of TGF-B receptor II and activated the ERK1/2 signaling pathway, leading to earlier entry of hair follicles into the anagen phase. The findings suggest that HAPLN1 could be a potential therapeutic target for promoting hair growth and treating hair loss with fewer side effects compared to current medications. The study involved 6 mice.

View this study on biomolther.org →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Minoxidil-Loaded Hyaluronic Acid Dissolving Microneedles to Alleviate Hair Loss in an Alopecia Animal Model

12 citations , February 2022 in “Acta Biomaterialia”

In this study, researchers found that dissolving microneedles made with hyaluronic acid enhanced the effectiveness of minoxidil in reducing hair loss and promoting hair growth in alopecia-affected mice more effectively than topical minoxidil alone, while using only 10% of the drug amount.

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations , January 2020 in “Skin Pharmacology and Physiology”

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells Through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

This study found that Activin B at 10 ng/mL may promote vibrissae follicle growth in mice by enhancing hair matrix cell proliferation and cell cycle progression via ERK signaling pathways.

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

321 citations , January 2012 in “Cell stem cell”

This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.

research Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents

127 citations , December 2007 in “Journal of Investigative Dermatology”

This review examines regenerative hair waves and complex hair cycle domains in transgenic mice, highlighting how these dynamic processes contribute to skin regeneration and the physiological regulation of organs, but reports no new experimental results.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

This article reviews the stages and regulation of the hair cycle, highlighting molecular regulators involved, but it does not present new research findings.

research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

231 citations , October 1999 in “Journal of Clinical Investigation”

This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.

research Human Hair Growth In Vitro

385 citations , November 1990 in “Journal of Cell Science”

This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.