336 citations
,
August 2015 in “European Journal of Epidemiology” This article reviews the design and objectives of the Rotterdam Study, as well as summarizes major findings, without reporting new results.
162 citations
,
August 2002 in “Survey of Ophthalmology” This study found that latanoprost induces significant growth and pigmentation of lashes and ancillary hairs, with effects mirroring both brief and chronic treatments observed in patients and animal models.
160 citations
,
January 2014 in “Seminars in cell & developmental biology” This review discusses the shared molecular and cellular processes in the early development stages of skin appendages like hair follicles, teeth, and mammary glands, reporting no new results.
159 citations
,
July 2006 in “Endocrine Reviews” This article discusses the influence of estrogens on hair follicle growth and metabolism, suggesting a significant role alongside androgens in hair growth control but reports no new clinical results.
152 citations
,
January 2004 in “Current anthropology” Humans lost body hair relatively recently in evolution.
115 citations
,
February 2016 in “Nature Communications” The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.
92 citations
,
September 2015 in “Journal of Lipid Research” This review discusses the roles of dermal white adipose tissue (dWAT) as an insulator, antibiotic, and regenerative tissue, highlighting its importance in systemic metabolism and immune function, but reports no new clinical results.
52 citations
,
October 2012 in “Journal of Dermatological Science” This review presents updated tables of mouse mutants with hair growth abnormalities to aid in understanding the molecular mechanisms of human hair disorders, but reports no new clinical results.
24 citations
,
June 2018 in “Expert Review of Pharmacoeconomics & Outcomes Research” This review discusses the potential of microneedle arrays for drug delivery and in the cosmetic market, but reports no new clinical results; factors for commercial therapeutic use are explored.
24 citations
,
May 2015 in “Schizophrenia Research” This study found that inhibiting the enzyme 5α-reductase with finasteride counteracted stress-induced prepulse inhibition deficits in socially isolated rats by altering neuroactive steroid concentrations in the brain.
20 citations
,
November 2019 in “Stem Cells” This study found that deleting the Hes1 gene disrupts hair regeneration by delaying anagen initiation and shortening the anagen phase, suggesting it's crucial for maintaining hair cycle homeostasis.
1 citations
,
February 2025 in “Scientific Reports” In this study, researchers found that CD4 is expressed on murine K5+ keratinocytes, and its expression is crucial for maintaining epidermal stem cell balance and wound repair capacity, particularly during aging.
1 citations
,
January 2016 in “Elsevier eBooks” This review examines the origins and mechanisms of tumor initiation in common skin cancers, but does not present new experimental findings; it emphasizes the need for further research on cancer stem cells.
December 2023 in “Revista Urología Colombiana / Colombian Urology Journal” This systematic review found that treatments for sickle cell disease-related priapism are clinically diverse, with etilefrine, pseudoephedrine/etilefrine-5 inhibitors, and finasteride appearing promising, but further research with robust study designs is needed to establish evidence-based practices.
9 citations
,
May 2024 in “Journal of Clinical & Translational Endocrinology” This review examines existing evidence on the efficacy and safety of gender affirming hormone therapy in relation to Gender Affirmation Surgery, but reports no new clinical results.
This study found that supercritical fluid extraction of germinated perilla seed significantly promoted hair follicle cell proliferation and gene expression related to hair growth, suggesting its potential as a natural treatment for hair loss.
November 2024 in “Plants” This study found that ethanolic extracts of Buebang 3 CMU may promote hair growth and prevent hair loss more effectively than minoxidil by enhancing bioactive compounds and activating key signaling pathways.
This study reports that Hair RiseTM microemulsion, made from plant extracts, significantly enhanced hair follicle cell growth and improved hair growth signaling pathways, suggesting it as a plant-based alternative for androgenetic alopecia treatment.
June 2019 in “International journal of dermatology and venereology” This review discusses the hedgehog signaling pathway's role in cutaneous tumors and hematological disorders, highlighting its potential as a therapeutic target, but reports no new clinical findings.
85 citations
,
March 2008 in “Journal of Cell Science” This study created transgenic mouse models with the LMNA gene mutation common in Hutchinson-Gilford progeria syndrome, revealing skin and teeth abnormalities related to transgene expression levels.
16 citations
,
December 2006 in “Chinese Medical Journal” This case report describes a 12-year-old boy with congenital insensitivity to pain with anhidrosis and progressing acro-osteolysis, highlighting the severe complications and the necessity for early intervention.
15 citations
,
September 2021 in “Frontiers in Endocrinology” This review discusses the impact of gender affirming hormone therapy on cardiovascular outcomes in transgender individuals and reports no new clinical results; the authors underscore the need for more comprehensive studies.
1 citations
,
January 2024 in “Frontiers in Psychology” In this study, researchers found that venture capitalists with below-average physical attractiveness are more influenced by the attractiveness of entrepreneurs when making investment decisions, and this sensitivity changes between investment rounds.
October 2024 in “SPIRE - Sciences Po Institutional REpository” This study highlights that human hair follicle dermal papilla cells and glypicans play crucial roles in regulating hair follicle stem cell differentiation.
April 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a specific genetic variant in the CCHCR1 gene that may contribute to alopecia areata through impaired keratinization, suggesting an alternative mechanism beyond autoimmune causes.
11 citations
,
March 2014 in “Journal of Investigative Dermatology” In this study, basal cell carcinoma developed in Ptch-deficient mice only after chemical treatment, not skin wounding, suggesting a second unknown event is necessary for tumor formation.
70 citations
,
February 2015 in “Expert Opinion on Drug Discovery” This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.
22 citations
,
February 2010 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice” This article reviews the evidence regarding the role of sex hormones in occult hyperadrenocorticism and reports no new findings, highlighting the unproven nature of their involvement.
1 citations
,
November 2022 in “Pharmaceutical research” In this study, the authors found that applying hypobaric pressure to the skin significantly increases the transdermal permeation of large molecules by enhancing diffusion, despite the associated skin stretching and hair follicle enlargement not fully explaining this effect.
January 2015 in “VetPharma” This review discusses Alopecia X in plush-coated dogs, noting that while treatments like melatonin and laser therapy have shown promise, the condition is generally considered a cosmetic issue without the need for therapy.