TLDR The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.
The document discusses the concept of occult hyperadrenocorticism in dogs, a condition where clinical signs and laboratory abnormalities suggest Cushing's syndrome, but standard diagnostic tests such as ACTH stimulation and low-dose dexamethasone suppression tests return normal results. A prevailing theory suggests that these signs may be due to an excess secretion of sex hormones rather than cortisol. However, the authors argue that the role of sex hormones in causing occult hyperadrenocorticism has not been conclusively proven. The article presents and evaluates evidence both supporting and challenging the significance of sex hormones in this atypical form of Cushing's syndrome.
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March 2010 in “The Veterinary clinics of North America. Small animal practice/Veterinary clinics of North America. Small animal practice” The cause of atypical Cushing's syndrome in dogs, possibly linked to sex hormones, is not yet proven.
