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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Doxil is an effective, modified chemotherapy drug with a unique toxicity profile and shows promise in treating certain cancers.

Cynoglossum amabile has medicinal potential but poses safety concerns due to liver toxicity.

Isotretinoin affects trace element levels and requires monitoring of liver and kidney functions.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

A rabbit with sebaceous adenitis was effectively treated with ciclosporin and medium-chain triglycerides.

Targeting thyroid hormone receptor α in liver cells may help treat liver fibrosis.

Hair mineral analysis might help diagnose diseases early, but standard methods are needed.

Dienogest combined with ethinylestradiol is a highly effective birth control that improves menstrual symptoms and has manageable side effects.

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

Certain metabolites are lower in women with PCOS and could be potential markers for the condition.

Vegetarian Indian women with PCOS have higher inflammation levels than non-vegetarians.

New signs like changes in blood markers, physical symptoms, and behavioral shifts may help detect hidden steroid use in athletes.

Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.

Origanum vulgare leaf extract reduces liver and kidney damage caused by finasteride in mice.

Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.

Tea seed oil in nanostructured carriers stimulates hair growth and feels less greasy when applied.

Isotretinoin is a preferred treatment for severe acne, often leading to long-term improvement, but requires careful monitoring due to potential side effects.

The document concludes that management strategies for PCOS are important due to its common occurrence and associated health risks.

More research is needed before using brown fat to treat polycystic ovary syndrome.

Bacteria can help skin regenerate through a process called IL-1β signaling.

Nanotechnology shows promise for better drug delivery and cancer treatment.

Some blood-thinning medications can increase the risk of bleeding, and certain factors like genetics and other health conditions affect their safety and effectiveness.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Finasteride effectively treats baldness but may cause sexual side effects.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

Oxidative stress is a key factor in the development of Polycystic Ovary Syndrome, and weight management can improve symptoms.

New understanding of the causes of primary cicatricial alopecia has led to better diagnosis and potential new treatments.

Nanomaterials in biomedicine can improve treatments but may have risks like toxicity, needing more safety research.