Analysis of Isotretinoin-Induced Alterations in the Levels of Plasma Trace Elements: Investigation of the Relationship Between Magnesium, Phosphorus, Potassium, Zinc, and Treatment-Related Side Effects

The study examined the effects of isotretinoin on plasma trace elements in 35 acne patients over 3 months. Significant increases in phosphorus, magnesium, and zinc levels were observed, while potassium levels decreased (p<0.05). Zinc levels rose more in men than women (p=7.3e-04). A strong correlation was found between magnesium and calcium (R>0.8). The changes in phosphorus and potassium suggest kidney function impacts. Monitoring liver and kidney functions, as well as phosphorus and potassium levels, is crucial before starting isotretinoin to manage side effects like fatigue, dry skin, chapped lips, hair loss, and altered sebum secretion.