Cicatricial Alopecia: Early Diagnosis and Treatment Strategies

January 2015 in “ Springer eBooks ”

Antonella Tosti, Eric L. Maranda, Bianca Maria Piraccini

Cicatricial Alopecia hair follicles lipid metabolism dysregulation PPAR-y lichen planopilaris PPAR-y modulation antimalarial drugs discoid lupus erythematosus retinoids systemic antibiotics folliculitis decalvans bacterial biofilm hair transplantation graft survival PPAR-gamma antimalarials DLE antibiotics biofilm

TLDR Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.

The 2015 document discusses Cicatricial Alopecia, a group of disorders causing permanent hair loss due to the destruction of hair follicles, and highlights the importance of early diagnosis and aggressive treatment. It suggests that lipid metabolism dysregulation and aberrant PPAR-y may contribute to lichen planopilaris, proposing PPAR-y modulation as a potential treatment. Antimalarial drugs are preferred for discoid lupus erythematosus, with retinoids as an alternative, while systemic antibiotics are primary for folliculitis decalvans, which may involve bacterial biofilm in its pathogenesis. Treatment outcomes vary, with some patients achieving complete or partial remission, and others seeing progression despite treatment. Hair transplantation is complicated by poor graft survival. The document notes the reliance on anecdotal evidence for treatment choices due to limited rigorous studies and does not provide the number of people in the studies mentioned, making it difficult to assess the strength of the evidence.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Keratosis Follicularis Spinulosa Decalvans in a Family

32 citations, February 2008 in “Journal of the American Academy of Dermatology”

KFSD is a genetic disorder causing hair loss and skin issues, with no effective treatment.

Related Community Posts Join

6 / 13 results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community lost my hair in a single year of treatment at 20 years old

in Finasteride/Dutasteride 90 upvotes 3 months ago

A 20-year-old lost significant hair after one year of treatment, using minoxidil, finasteride, and later dutasteride. They are considering adding RU58841 but are advised to return to finasteride and minoxidil for a year before deciding.

community Exploring Bryan Johnson's Hair Routine In Detail

in Research/Science 65 upvotes 10 months ago

Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 5 months ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.