Cicatricial Alopecia: Early Diagnosis and Treatment Strategies

    January 2015 in “ Springer eBooks
    Antonella Tosti, Eric L. Maranda, Bianca Maria Piraccini
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    TLDR Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.
    The 2015 document discusses Cicatricial Alopecia, a group of disorders causing permanent hair loss due to the destruction of hair follicles, and highlights the importance of early diagnosis and aggressive treatment. It suggests that lipid metabolism dysregulation and aberrant PPAR-y may contribute to lichen planopilaris, proposing PPAR-y modulation as a potential treatment. Antimalarial drugs are preferred for discoid lupus erythematosus, with retinoids as an alternative, while systemic antibiotics are primary for folliculitis decalvans, which may involve bacterial biofilm in its pathogenesis. Treatment outcomes vary, with some patients achieving complete or partial remission, and others seeing progression despite treatment. Hair transplantation is complicated by poor graft survival. The document notes the reliance on anecdotal evidence for treatment choices due to limited rigorous studies and does not provide the number of people in the studies mentioned, making it difficult to assess the strength of the evidence.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 7 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 1 week ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  63 upvotes 1 year ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

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