Cicatricial Alopecia: Early Diagnosis and Treatment Strategies

January 2015 in “ Springer eBooks ”

Antonella Tosti, Eric L. Maranda, Bianca Maria Piraccini

Cicatricial Alopecia hair follicles lipid metabolism dysregulation PPAR-y lichen planopilaris PPAR-y modulation antimalarial drugs discoid lupus erythematosus retinoids systemic antibiotics folliculitis decalvans bacterial biofilm hair transplantation graft survival PPAR-gamma antimalarials DLE antibiotics biofilm

TLDR Early diagnosis and aggressive treatment are crucial for Cicatricial Alopecia, and treatment effectiveness varies among patients.

The 2015 document discusses Cicatricial Alopecia, a group of disorders causing permanent hair loss due to the destruction of hair follicles, and highlights the importance of early diagnosis and aggressive treatment. It suggests that lipid metabolism dysregulation and aberrant PPAR-y may contribute to lichen planopilaris, proposing PPAR-y modulation as a potential treatment. Antimalarial drugs are preferred for discoid lupus erythematosus, with retinoids as an alternative, while systemic antibiotics are primary for folliculitis decalvans, which may involve bacterial biofilm in its pathogenesis. Treatment outcomes vary, with some patients achieving complete or partial remission, and others seeing progression despite treatment. Hair transplantation is complicated by poor graft survival. The document notes the reliance on anecdotal evidence for treatment choices due to limited rigorous studies and does not provide the number of people in the studies mentioned, making it difficult to assess the strength of the evidence.

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research Keratosis Follicularis Spinulosa Decalvans in a Family

32 citations, February 2008 in “Journal of the American Academy of Dermatology”

KFSD is a genetic disorder causing hair loss and skin issues, with no effective treatment.

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