Successful Treatment of Sebaceous Adenitis in a Rabbit with Ciclosporin and Triglycerides

A 4-year-old rabbit with chronic exfoliative dermatitis and patchy alopecia was diagnosed with sebaceous adenitis after skin scrapings, fungal culture, blood tests, and radiographic examination ruled out other conditions. The rabbit was successfully treated with oral ciclosporin dissolved in Miglyol 812, a medium-chain triglyceride solution, along with essential fatty acids and topical propylene glycol sprays. Within 2 months, the rabbit showed complete regression of skin lesions and hair regrowth, with normal sebaceous glands and active hair follicles observed in control biopsies. Serum chemistry values remained normal throughout treatment. When the treatment was switched to a different formulation of ciclosporin without Miglyol, the rabbit's condition worsened, but improved again with the reintroduction of Miglyol 812. The study suggests that sebaceous adenitis in rabbits may be an autoimmune condition with a lipid metabolism defect, and that the combination of ciclosporin and Miglyol 812 is an effective treatment.