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Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Treatments that reduce oxidative stress and fix mitochondrial problems may help heal chronic wounds.

Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.

Niosomes improve minoxidil skin delivery for hair loss treatment.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Low-Level Laser Therapy is effective and safe for hair growth with minimal side effects.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Pig skin is a good substitute for human skin to measure drug absorption, but differences in skin structure and enzymes across species must be considered.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

The document recommends using both clinical evaluation and various measurement methods to assess skin greasiness, considering factors like temperature and hormones.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

PEVs improve minoxidil skin penetration, increasing hair growth.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Male pattern baldness involves hormones and cell signals affecting hair growth.

Folliculitis decalvans is a rare scalp condition causing scarring hair loss, treated with long-term antibiotics and other medications, but it often comes back and is hard to manage.

Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.

New micelle solutions greatly improve skin delivery of certain antifungal drugs.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

One minoxidil-sensitive potassium channel exists in human hair follicles.

Fullerenes show potential in skin care but need more safety research.