Nitroxide Pharmaceutical Development for Age-Related Degeneration and Disease

November 2015 in “ Frontiers in Genetics ”

Jacob A. Zarling, Vienna E. Brunt, Anne K. Vallerga, Weixing Li, Albert Tao, David A. Zarling, Christopher T. Minson

nitroxide Tempol Tempol Hydroxylamine TP-H OT-551 cutaneous microvascular dysfunction radiation-induced skin burns hair loss oxidative stress chronic inflammation topical formulation oral formulation injectable formulation TP TP-H prodrug

TLDR Nitroxide drugs can safely and effectively treat age-related diseases like macular degeneration and cardiovascular issues.

The document discussed the development of nitroxide-based pharmaceuticals, particularly Tempol (TP), Tempol Hydroxylamine (TP-H), and OT-551, for treating age-related macular degeneration (AMD) and cardiovascular disease (CVD). These drugs aimed to reduce oxidative stress and inflammation, with clinical trials showing that OT-551 preserved visual acuity in over 200 AMD patients without adverse events over up to 2 years. OT-551 also showed promise in preventing radiation-induced skin burns and hair loss in brain cancer patients. Tempol improved microvascular function in smokers. The findings supported further development of nitroxide agents for various age-related and smoking-related conditions.

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