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Self-amplifying RNA could be a better option for protein replacement therapy with lower doses and lasting effects, but delivering it into cells is still challenging.

Immune cells are essential for early hair and skin development and healing.

Changes in skin microbes play a role in some skin diseases and could lead to new treatments.

The cancer drugs bortezomib and lenalidomide cause skin side effects in many patients.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

New targeted immunotherapies are improving treatment for inflammatory skin diseases.

Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.

New tools show that in fish, NPY increases feeding and somatostatin decreases it.

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

The document concludes that more research is needed to reduce frequent hospital visits, addiction medicine education improves with specific training, early breast cancer surgery findings are emerging, nipple smears are not very accurate, surgery for older melanoma patients doesn't extend life, a genetic condition in infants can often be treated with one drug, doctors are inconsistent with blood clot medication, a certain gene may protect against cell damage, muscle gene overexpression affects many other genes, and some mitochondrial genes are less active in mice with tumors.

Oral isotretinoin for severe acne can change hormone levels but does not significantly affect ovarian function.

COVID-19 protective measures led to skin irritation, hair loss, and brittle nails; using skin-friendly products and a healthy diet is recommended.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Removing myelin protein zero-like 3 in mice leads to better metabolism and resistance to obesity.

A protein called lfTSLP is important in causing allergic and other skin diseases and could be a target for treatment.

Vitamin D and estrogen may help protect heart and kidney health, and maintaining sufficient vitamin D levels could be especially beneficial for African Americans, postmenopausal women, and people with chronic kidney disease.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.

The volumes provide comprehensive guidance on aesthetic and reconstructive head and neck surgery.

Tattooing helps treat skin conditions, reconstruct nipple-areola, mark radiation fields, and locate lesions.

FDG PET/CT scans can change cancer treatment plans for dogs.

MSC-Exos can aid organ development and offer therapeutic benefits for various conditions.

Skin problems from transplant drugs are common and need careful management in organ transplant patients.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

CRISPR/Cas9 has improved precision and control but still faces clinical challenges.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Certain drugs that block specific enzymes can help treat prostate diseases.

The guide explains how to study human skin fat cells and their tissue, aiming to improve research and medical treatments.

Parkinson's disease is linked to skin disorders and skin cells help in studying the disease.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.