12 citations
,
May 2005 in “Current obstetrics and gynaecology/Current obstetrics & gynaecology” This review discusses the causes and treatment strategies for hirsutism, emphasizing that combination therapy targeting androgen suppression and hair removal techniques is most effective; no new clinical results are reported.
June 2002 in “Current obstetrics and gynaecology/Current obstetrics & gynaecology” This article discusses various causes and treatment options for hirsutism in women, highlighting the effectiveness of cyproterone acetate and the importance of weight reduction, without presenting new research findings.
4 citations
,
October 2023 in “African Journal of Urology” This study found that hypospadias in male children is significantly associated with genetic polymorphisms in the Steroid 5 alpha reductase type 2 gene, higher parental age, consanguinity, rural residence, and preterm labor, with maternal age and rural residence being the strongest independent predictors.
77 citations
,
April 2009 in “British Journal of Dermatology” In this study, genetic variation in the CYP19A1 gene, particularly the common rs4646 C allele, was associated with an increased risk of female pattern hair loss, especially in women under 40.
46 citations
,
October 1999 in “Journal of The American Academy of Dermatology” This study found that finasteride at 1 mg/day was the most effective dose for treating male pattern hair loss, with similar efficacy to 5 mg/day and better results than lower doses.
27 citations
,
October 2011 in “British Journal of Dermatology” This study builds on previous findings by associating female pattern hair loss with gene polymorphisms related to oestrogen activity, suggesting oestrogen's role in the condition.
24 citations
,
March 1987 in “Journal of The American Academy of Dermatology” This study found that 1% and 2% topical minoxidil solutions resulted in clinically noticeable hair growth compared to lower doses or placebo in men with male pattern baldness.
February 2025 in “Clinical Cosmetic and Investigational Dermatology” This study used Mendelian randomization to explore associations between 1400 blood metabolites and female-pattern hair loss, finding 23 metabolites and 4 metabolic ratios linked to the condition, while identifying fructose/mannose metabolism as a significant pathway.
September 2024 in “Journal of the American Academy of Dermatology” This study found that female pattern hair loss patients who used gratitude journals saw notable improvements in perceived hair loss and quality of life over one month compared to controls, with 83% reporting improvement in hair loss versus 33% in the control group.
July 2024 in “Journal of Investigative Dermatology” Most women continued using oral minoxidil for hair loss despite mild to moderate side effects.
August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology” This study reported variable expression levels of TRα and CRABPII genes during the prenatal development of cashmere goats, contributing to an understanding of hair follicle formation in these animals.
November 2022 in “Journal of Investigative Dermatology” This study found a minimal overall contribution of rare coding variants to male-pattern hair loss but identified significant associations with rare variants in 125 genes, including novel candidate genes.
5 citations
,
August 2013 in “Facial plastic surgery clinics of North America” This article discusses managing extensive hair loss with limited transplant options and suggests a frontal forelock-type pattern is effective for both already bald men and younger patients at risk; it reports no new clinical results.
215 citations
,
November 2006 in “Journal of The American Academy of Dermatology” This study found that dutasteride increased scalp hair growth in men with male pattern hair loss, particularly at a 2.5 mg dose, and was more effective than finasteride over 24 weeks.
212 citations
,
September 2008 in “Journal of The American Academy of Dermatology” This review discusses the various treatment options for male and female pattern hair loss and provides no new clinical results; the authors outline the most effective strategies based on existing evidence.
203 citations
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December 2004 in “Journal of The American Academy of Dermatology” This article reviews the historical developments in understanding and treating male pattern hair loss, emphasizing the role of dihydrotestosterone and 5α-reductase inhibitors, but reports no new clinical findings.
187 citations
,
June 1999 in “Journal of The American Academy of Dermatology” This study reported that finasteride 1 mg/day significantly increased hair growth and slowed hair loss in men with frontal scalp hair thinning over one year, and these benefits continued or improved in the second year.
149 citations
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July 2017 in “PLoS Biology” This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.
59 citations
,
September 1994 in “The Journal of Clinical Endocrinology and Metabolism” This study found that 4 weeks of finasteride treatment significantly decreased DHT levels in bald scalp to levels similar to hair-containing scalp in men with male pattern baldness.
52 citations
,
March 1987 in “Journal of the American Academy of Dermatology” This study found that men with rapidly progressive male pattern baldness had elevated serum dehydroepiandrosterone sulfate levels, suggesting that adrenal hyperactivity may contribute to alopecia in genetically susceptible young men.
51 citations
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January 1989 in “Journal of Investigative Dermatology” This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.
44 citations
,
February 2023 in “Cell” In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.
30 citations
,
October 2002 in “Journal of The American Academy of Dermatology” Use "female pattern hair loss" term, finasteride may help, more research needed.
29 citations
,
February 2016 in “Scandinavian journal of urology” This study suggests a possible link between late puberty onset and decreased prostate cancer risk, while over-the-counter ibuprofen use was associated with increased risk.
29 citations
,
March 2010 in “Cancer epidemiology” This study found that early-onset male pattern baldness was associated with a reduced relative risk of prostate cancer.
29 citations
,
February 1989 in “Journal of Cutaneous Pathology” This case report identifies a new type of hair matrix tumor called "rippled pattern trichomatricoma," distinguished by its unique cell arrangement and differentiation features.
27 citations
,
December 2005 in “Journal of Cosmetic Dermatology” This study found that topical application of niacin derivatives significantly increased hair fullness in women with female pattern hair loss compared to a placebo after six months.
21 citations
,
January 2007 in “Australasian Journal of Dermatology” This case report describes how a 53-year-old woman with female pattern hair loss experienced further hair regrowth when topical minoxidil was added to her spironolactone treatment after initial results plateaued.
19 citations
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November 2012 in “BJUI” In this study, researchers observed that the sexual effects of dihydrotestosterone deprivation using finasteride may vary by handedness, with right-handed men often experiencing lower sexual function and left-handed men showing no effect or improvement.
11 citations
,
March 2021 in “Cleveland Clinic Journal of Medicine” In this overview, the authors note that both pharmacologic and nonpharmacologic treatments are effective for pattern hair loss, emphasizing early detection and intervention to maintain hair.