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Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

January 2024 in “Aging”

New insights into cell communication in psoriasis suggest innovative drug treatments.

research Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

July 2020 in “Bioinformatics and Bioengineering”

Found key genes affecting hair loss, immune response, and skin development; more research needed for better treatments.

The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

70 citations, December 2004 in “Differentiation”

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.

research Identification of Differentially Expressed Genes in Actinic Keratosis Samples Treated with Ingenol Mebutate Gel

4 citations, May 2020 in “PLOS ONE”

Ingenol mebutate gel changes gene expression related to skin development and immune response in actinic keratosis.

research Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

4 citations, September 2019 in “Biomedical Papers/Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc Czech Republic”

CD2 might be a new treatment target for patchy alopecia areata.

research MOF-Mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

1 citations, July 2023 in “Nature communications”

MOF controls key genes for skin development by regulating mitochondrial and ciliary functions.

research Spatio-Temporal Regulation of Gene Expression Defines Subpopulations of Epidermal Stem Cells

1 citations, November 2020 in “Biochemical Society transactions”

Different types of skin stem cells can change and adapt, which is important for developing new treatments.

research MOF-Mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

MOF controls skin development by regulating genes for mitochondria and cilia.

research Autosomal Recessive Monilethrix: Novel Variants of the DSG4 Gene in Three Chinese Families

5 citations, February 2022 in “Molecular genetics & genomic medicine”

New gene variants linked to a rare inherited hair loss disorder were found in three Chinese families.

research Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Researchers made a detailed map of gene activity for different parts of human hair follicles to help create targeted hair disorder treatments.

research Case of Epidermolytic Ichthyosis with a Novel L157P Mutation in KRT10 Complicated by Hypercalcemia

October 2011 in “Journal of dermatology”

A man with a rare skin condition and a new gene mutation developed high calcium levels due to his treatment.

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

417 citations, September 2005 in “PLoS biology”

Understanding gene expression in hair follicles can reveal insights into hair growth and disorders.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation

68 citations, December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

HOXC13 is essential for hair and nail development by regulating Foxn1.

research The Lanceolate Hair Rat Phenotype Results from a Missense Mutation in a Calcium Coordinating Site of the Desmoglein 4 Gene

50 citations, February 2004 in “Genomics”

A gene mutation causes lanceolate hair in rats by disrupting hair shaft integrity.

research Position Effect on FGF13 Associated with X-Linked Congenital Generalized Hypertrichosis

44 citations, April 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

FGF13 gene changes cause excessive hair growth in a rare condition.

research Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

43 citations, August 2018 in “Cell Stem Cell”

Hoxc genes control hair growth through Wnt signaling.

research Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm

26 citations, December 2011 in “Journal of Investigative Dermatology”

New gene identification techniques have improved the understanding and classification of inherited hair disorders.

research Alopecia Areata Susceptibility Variant in MHC Region Impacts Expressions of Genes Contributing to Hair Keratinization and Is Involved in Hair Loss

19 citations, July 2020 in “EBioMedicine”

A gene variant increases the risk of a type of hair loss by affecting hair protein production.

research Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis

19 citations, March 2018 in “Journal of Investigative Dermatology”

The gene Msx2 is crucial for hair follicle regeneration during wound healing.

research Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

15 citations, December 2021 in “Pharmaceutics”

The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.

research Cutaneous Transcriptome Analysis in NIH Hairless Mice

7 citations, August 2017 in “PloS one”

Key genes linked to hair growth and cancer were identified in hairless mice.

research Revisiting the Significance of Keratin Expression in Complex Epithelia

6 citations, October 2022 in “Journal of cell science”

Keratin genes change gradually during skin cell development and should be used carefully as biomarkers.

research Genetic Control and Involvement in Hair Fiber Traits

5 citations, December 2011 in “Springer eBooks”

research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

3 citations, March 2023 in “International journal of molecular sciences”

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

3 citations, November 2021 in “Frontiers in Genetics”

Certain genes are linked to the quality of cashmere in goats.

research Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits

2 citations, December 2022 in “International journal of molecular sciences”

Plucked hairs can be used instead of skin biopsies to study hair traits because they contain specific cells related to hair.

research Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia

2 citations, October 2021 in “JID innovations”

Uterine leiomyomas don't significantly change gene expression in the scalp of people with Central Centrifugal Cicatricial Alopecia.

Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness

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Research

research Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

research Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

research The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

research Identification of Differentially Expressed Genes in Actinic Keratosis Samples Treated with Ingenol Mebutate Gel

research Bioinformatics Analysis of Genes Associated with Patchy-Type Alopecia Areata: CD2 May Be a New Therapeutic Target

research MOF-Mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

research Spatio-Temporal Regulation of Gene Expression Defines Subpopulations of Epidermal Stem Cells

research MOF-Mediated Histone H4 Lysine 16 Acetylation Governs Mitochondrial and Ciliary Functions by Controlling Gene Promoters

research Autosomal Recessive Monilethrix: Novel Variants of the DSG4 Gene in Three Chinese Families

research Combining Laser Capture Microdissection and RNAseq Analysis to Generate a Human Anagen Hair Follicle Transcriptome Atlas

research Case of Epidermolytic Ichthyosis with a Novel L157P Mutation in KRT10 Complicated by Hypercalcemia

research Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation

research The Lanceolate Hair Rat Phenotype Results from a Missense Mutation in a Calcium Coordinating Site of the Desmoglein 4 Gene

research Position Effect on FGF13 Associated with X-Linked Congenital Generalized Hypertrichosis

research Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration

research Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm

research Alopecia Areata Susceptibility Variant in MHC Region Impacts Expressions of Genes Contributing to Hair Keratinization and Is Involved in Hair Loss

research Msx2 Supports Epidermal Competency During Wound-Induced Hair Follicle Neogenesis

research Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

research Cutaneous Transcriptome Analysis in NIH Hairless Mice

research Revisiting the Significance of Keratin Expression in Complex Epithelia

research Genetic Control and Involvement in Hair Fiber Traits

research A Kaleidoscope of Keratin Gene Expression and the Mosaic of Its Regulatory Mechanisms

research Single-Cell Sequencing Reveals Differential Cell Types in Skin Tissues of Liaoning Cashmere Goats and Key Genes Potentially Related to the Fineness of Cashmere Fiber

research Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits

research Presence of Uterine Leiomyomas Has No Significant Impact on Gene Expression Profile in the Scalp of Patients with Central Centrifugal Cicatricial Alopecia

research Complementary Evolution of Coding and Noncoding Sequence Underlies Mammalian Hairlessness

research Revisiting the Significance of Keratin Expression in Complex Epithelia

research Independent DSG4 Frameshift Variants in Cats with Hair Shaft Dystrophy