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Glossary Insulin-like Growth Factor Binding Proteins

regulate insulin-like growth factors' activity and availability

Insulin-like Growth Factor Binding Proteins (IGFBPs) are a group of proteins that bind to insulin-like growth factors (IGFs), which are hormones involved in growth and development. By binding to IGFs, IGFBPs regulate their activity, availability, and interaction with IGF receptors, thereby playing a crucial role in cell growth, differentiation, and metabolism.

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research Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts**This work was supported by NIDDK Grant DK-45227 and a scholarship (to R.C.P.) from Fundacao Coordenacao de Aperfeicoa mento de Pessoal de Nivel Superior (CAPES), Universidade de Sao Paulo (Sao Paulo, Brazil).

43 citations , January 1999 in “Endocrinology”

This study found that cortisol increases mac25/IGFBP-rP1 expression in osteoblast-enriched cells from fetal rat calvariae, indicating transcriptional regulation which may influence IGF and insulin effects in bone.

research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

This study found that IGF1, retinoic acid, and dexamethasone increase IGFBP-3 production in cultured human dermal papilla cells, potentially inhibiting IGF1 action on hair growth.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

26 citations , June 2000 in “Journal of The American Academy of Dermatology”

This study found that older men with vertex balding had lower levels of IGFBP-3 and higher levels of IGF-1 in their plasma.

The Association Between Low Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 With Hair Loss in Women: A Case-Control Study in Basrah, Iraq

research The Association between Low (or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case-Control Study in Basrah, Iraq

March 2026 in “European Journal of Medical and Health Research”

In this case-control study, researchers observed that women with female pattern hair loss exhibited significantly lower serum IGF-1 levels than controls, while IGFBP-3 levels showed no significant difference, suggesting a potential role for IGF-1 in the condition.

research Vertex balding, plasma insulin-like growth factor 1, and insulin-like growth factor binding protein 3

3 citations , June 2000 in “Journal of The American Academy of Dermatology”

This study found that older men with vertex balding have lower circulating levels of the protein IGFBP-3 and higher levels of IGF-1.

research The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq

July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels than controls, suggesting a possible role for IGF-1 in this condition.

research The Association Between Low (Or Reduced) Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 with Hair Loss in Women. A Case- Control Study in Basrah City of Iraq

July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

This study found that women with female pattern hair loss had significantly lower serum IGF-1 levels compared to controls, but no significant association between IGFBP-3 levels and hair loss severity was observed.

research Insulin-like growth factor 1 and hair growth

98 citations , November 1999 in “Dermatology Online Journal”

This review discusses the effects of IGF-1 on hair follicle cell proliferation and differentiation, highlighting its roles in paracrine signaling, apoptosis prevention, and hair growth, but reports no new clinical results.

research Study on Expression of Insulin-like Growth Factor-binding Protein-3and -5(IGFBP-3 and IGFBP-5)in the Skin of Inner Mongolia Cashmere Goat

January 2013 in “China Animal Husbandry & Veterinary Medicine”

This study found that IGFBP-5 may play a significant regulatory role in the hair follicle development of Inner Mongolia Cashmere goats, with more consistent expression patterns across different stages.

research Insulin-like growth factor-1: roles in androgenetic alopecia

27 citations , February 2014 in “Experimental Dermatology”

This study found that dermal papilla cells from balding scalp follicles secrete significantly less insulin-like growth factor-1 and its binding proteins, suggesting a mechanism contributing to male pattern baldness.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts

20 citations , January 2019 in “Journal of dermatological science”

This study suggests that androgens enhance growth factor production in dermal fibroblasts, which in turn may alter keratinocyte differentiation and contribute to acne lesion formation.

research Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth

21 citations , January 2018 in “The Korean Journal of Physiology and Pharmacology”

This study found that human umbilical cord blood mesenchymal stem cells promoted hair growth by advancing anagen onset and increasing hair follicle regeneration in an in vivo model.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

In this study, researchers observed that hyperandrogenic PCOS patients exhibited distinct miRNA and TGFβ signaling gene expression patterns in granulosa cells, suggesting these factors may play a role in PCOS pathogenesis.

research Skin Deep and Deeper: Multiple Pathways in Basal Cell Carcinogenesis

5 citations , September 2010 in “Cancer Prevention Research”

This perspective discusses Villani et al.'s findings on the role of the IGF regulatory protein Igfbp2 in basal cell carcinogenesis and highlights potential therapeutic and preventive targets, while raising questions about the cell of origin.

research Effects of oxytocin on the hair growth ability of dermal papilla cells

October 2023 in “Scientific Reports”

This study explored the effects of oxytocin on hair growth and found that it upregulated growth-promoting factors in dermal papilla cells and hair follicle organoids, suggesting potential for developing new alopecia treatments.

research Involvement of DKK1 secreted from adipose‐derived stem cells in alopecia areata

November 2023 in “Cell Proliferation”

This study found that adipose-derived stem cells with DKK1 knocked out using CRISPR/Cas9 promoted hair growth in an alopecia areata model more effectively than untreated stem cells, suggesting DKK1 is a potential therapeutic target for this condition.

Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

research Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways

39 citations , June 2013 in “Journal of Cosmetic Dermatology”

This study found that combining herbal extracts with PRP increased human dermal papilla cell proliferation via ERK and Akt protein regulation, suggesting its potential for developing hair growth therapies.

research CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata

January 2024 in “International Journal of Molecular Sciences”

This study found that subcutaneous injection of a CXCL12 neutralizing antibody significantly promoted hair growth in androgenic alopecia and inhibited hair loss in alopecia areata in mouse models, suggesting its potential as a promising treatment for hair loss.

research Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

53 citations , November 2021 in “Molecular Human Reproduction”

This study found that the antioxidant N-acetylcysteine attenuated ferroptosis in the uterus and placenta of a PCOS-like rat model, indicating its potential as a therapeutic strategy for PCOS-related complications.

Effects of Glucagon-Like Peptide-1 Receptor Agonists on Skin Homeostasis and Aging Processes

research Effects of Glucagon-like Peptide-1 Receptor Agonists on Skin Homeostasis and Skin Aging Processes

April 2026 in “Journal of Clinical Medicine”

This review summarizes recent research into the effects of GLP-1 receptor agonists on skin processes, noting potential benefits for wound healing but also potential cosmetic concerns like facial fat loss and decreased collagen, highlighting the need for more clinical studies to clarify their dermatological impact.

research Polysaccharides from the Sargassum and Brown Algae Genus: Extraction, Purification, and Their Potential Therapeutic Applications

2 citations , June 2023 in “Plants”

This paper reviews extraction methods for obtaining polysaccharides from brown macroalgae like Sargassum, highlighting their antiviral, antimicrobial, and antitumoral bioactivities in both in vivo and in vitro studies, while also discussing challenges in research and commercialization of Sargassum-based products.

research Human Follicular Papilla Cells Carry Out Nonadipose Tissue Production of Leptin

37 citations , December 2001 in “Journal of Investigative Dermatology”

This study found that human follicular papilla cells in the scalp produce leptin and express functional leptin receptors, suggesting leptin's significant role in hair biology.

research Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review

65 citations , April 2018 in “Oncotarget”

This review discusses the potential carcinogenic effects of anabolic androgenic steroids, particularly regarding Leydig cell tumors, and highlights the need for preventive information campaigns due to associated health risks.

Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK

research Minoxidil prevents 3,4-methylenedioxymethamphetamine-induced serotonin depletions: role of mitochondrial ATP-sensitive potassium channels, Akt and ERK

22 citations , February 2008 in “Journal of Neurochemistry”

This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.

research Industry update: the latest developments in the field of therapeutic delivery, July 2018

1 citations , November 2018 in “Therapeutic Delivery”

This industry update reports on various advancements in therapeutic delivery during July 2018, highlighting active mergers, collaborations, and potential developments across fields like gene therapy, immuno-oncology, and rare diseases treatment; however, no new clinical results are presented.

Guava Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

research Guava (Psidium guajava L.) Leaf Extract as Bioactive Substances for Anti-Androgen and Antioxidant Activities

7 citations , December 2022 in “Plants”

This study suggests that guava leaf extract may inhibit hair loss by downregulating genes involved in androgen synthesis, potentially offering a natural alternative for treating androgenetic alopecia.

research Dermo-Cosmetic Benefits of Marine Macroalgae-Derived Phenolic Compounds

9 citations , November 2022 in “Applied sciences”

This review explores marine algae-derived phenolic compounds and their potential cosmeceutical benefits, but reports no new clinical results.

research Green tea: Health benefits

86 citations , January 2008 in “Journal of nutritional & environmental medicine”

This review examines the health benefits of green tea, focusing on catechins, but reports no new findings; the authors emphasize potential benefits for conditions like cancer, heart disease, and diabetes.

research Keratinocyte-Specific Onset of Serine Protease BSSP Expression in Experimental Carcinogenesis

26 citations , September 2001 in “Journal of Investigative Dermatology”

This study found that the serine protease BSSP is strongly expressed in mouse skin during carcinogenesis and is upregulated independently of c-Fos and unaffected by glucocorticoids.

research Effect of finasteride on ovulation induction in nonresponder (hyperandrogenic) polycystic ovary syndrome (PCOS) women

6 citations , April 2009 in “Fertility and Sterility”

Finasteride helps induce ovulation in nonresponder PCOS women.