Cortisol Enhances the Expression of mac25/Insulin-Like Growth Factor-Binding Protein-Related Protein-1 in Cultured Osteoblasts

    January 1999 in “ Endocrinology ”
    Renata C. Pereira, F. Blanquaert, Ernesto Canalis
    TLDR Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.
    The study found that cortisol enhanced the expression of mac25/IGFBP-rP1 in osteoblast-enriched cells from 22-day-old fetal rat calvariae, with a time- and dose-dependent increase in mRNA levels observed after treatment with cortisol. This effect was achieved through transcriptional mechanisms, as indicated by nuclear run-on assays, and was not altered by cycloheximide. Other hormones like retinoic acid also increased mac25/IGFBP-rP1 mRNA levels, while 17beta-estradiol, testosterone, and others did not. The increased expression of IGFBP-rP1, which binds IGFs and insulin, could be significant in understanding cortisol's inhibitory effects on bone.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 199 results

      community Low cortisol it is due the fin

      in Finasteride/Dutasteride  7 upvotes 4 months ago
      The user has been taking 1mg finasteride daily for a year with no improvement in hair loss and reports low cortisol levels, sleep issues, and anxiety changes. The conversation includes discussions on the potential effects of finasteride on cortisol and neurosteroids, with suggestions to consult a doctor and consider other factors.

      community Result of my cortisol, prolactin, testosterone, ACTH blood test,

      in Update 1 month ago
      OP is using 5% minoxidil and a foligain supplement for hair loss, with blood test results showing high cortisol levels. OP is considering starting finasteride, while another user shares their experience with finasteride and hair loss challenges due to malabsorption issues.

      community Female AGA - Low Cortisol/Low DHEA

      in Female  6 upvotes 2 years ago
      Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

      community How to reduce cortisol (stress hormone) naturally?

      in Chat  38 upvotes 3 years ago
      The conversation discusses natural ways to reduce cortisol, such as avoiding caffeine, getting proper sleep, syncing with the sun, walking in nature, breathing exercises, increasing calories, and not doing keto. Magnesium supplements are recommended for stress reduction.

    Similar Research

    5 / 1000+ results