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Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

The research found genetic differences in identical twins that could explain why one twin has a disease while the other does not.

A genetic mutation in the EDA gene causes hypohidrotic ectodermal dysplasia in cats.

BMP2 and BMP7 have opposite roles in feather formation.

MPZL3 is crucial for seborrheic dermatitis development.

Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.

Caffeine penetrates skin quickly through open hair follicles, but less through closed ones, with levels becoming equal after 22 hours.

CCDC22 and CCDC93 are essential for root and root hair growth in Arabidopsis.

Some nutraceuticals may help in COVID-19 prevention and treatment, but more research is needed.

African plants can treat hair issues and may help with diabetes.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.

Some herbal ingredients like linalool and tea tree oil have anti-dandruff properties and are safe for use in shampoos.

Genomic approach finds new possible treatments for hair loss.

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.

A gene in Sebekia benihana, CYP-sb21, is needed for a specific reaction on the drug Cyclosporine A, which could be important for hair growth without affecting the immune system.

Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

FKBP10 and FBN2 are key proteins for hair growth in cashmere goats.

Natural products show promise for new hair loss treatments.

Addressing underrepresentation in Parkinson's research is crucial for better treatments and understanding.

BFNB could be a promising treatment for hair growth.

Three specific genetic variants cause severe skin issues in children with EBS, highlighting the need for early genetic screening.

Hibiscus rosa-sinensis is used in traditional medicine and is safe in high doses, with various health benefits.

CD201+ fascia progenitors are essential for wound healing and could be targeted for treating skin conditions.

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

IGF-1R may play a role in female hair loss and could be a treatment target.

Some canine hair follicle tumors contain amyloid deposits, with a protein called CK5 involved in their formation.