4 citations
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January 2020 in “Skin appendage disorders” This case report describes a unique presentation of frontal fibrosing alopecia characterized by a hair loss pattern that resembles the Greek letter upsilon, supported by trichoscopic and histological findings.
August 2015 in “Dermatología Argentina” This study reviewed 18 postmenopausal women with frontal fibrosing alopecia, noting frontotemporal hairline recession and eyebrow loss, often treated with steroids, triamcinolone, and other medications.
November 2025 in “Frontiers in Nutrition” This study observed that in individuals with stroke, the GNRI has a significant negative association with FI and FISI, mediated by the SII index and OBS, suggesting the importance of anti-inflammatory and antioxidant strategies to reduce FI risk.
April 2026 in “Case Reports in Dermatology” In this case report, a woman with Graham-Little-Piccardi-Lassueur Syndrome and hidradenitis suppurativa showed significant improvements in both conditions after six months of treatment with tofacitinib, a Janus Kinase inhibitor, with no recurrence or adverse events noted during a two-year follow-up.
September 2022 in “XXXIX Congresso Brasileiro de Reumatologia” In this case report, a 42-year-old woman with cutaneous dermatomyositis showed significant improvement, including reduction of erythema, pruritus, and scaling, after starting JAK inhibitor tofacitinib, especially when conventional systemic treatments failed and intravenous immune globulin wasn't viable.
November 2023 in “Journal of Cosmetic Dermatology” In this study, tofacitinib treatment significantly reduced hair loss on the head and body, as well as nail involvement, in patients with alopecia areata over 18 months, with minimal side effects reported.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.
In this in vitro study, Yifa Compound Prescription was reported to enhance human hair follicle growth and increase VEGF mRNA expression compared to blank serum.
6 citations
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October 2023 in “Animal Biotechnology” This study found that a 22-bp InDel polymorphism in the FGF7 gene was significantly associated with growth traits in goats, with genotypes ID and/or II linked to better growth compared to genotype DD, indicating its potential as a molecular marker in breeding programs.
December 2018 in “International journal of women’s dermatology” This case report highlights that frontal fibrosing alopecia may be underrecognized in young women and notes that no single treatment regimen has been proven consistently effective for this condition.
This article discusses the features and increasing prevalence of frontal fibrosing alopecia, a type of scarring hair loss, and reports no new clinical results.
1 citations
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January 2020 in “Skin appendage disorders” Finasteride may help treat frontal fibrosing alopecia, but more research is needed.
6 citations
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January 2017 in “British Journal of Dermatology” This article reviews frontal fibrosing alopecia, exploring its characteristics, demographics, and associated conditions, and calls for controlled trials due to an increase in worldwide cases; it reports no new findings.
September 2023 in “Journal of the American Academy of Dermatology” This study found that in participants with notalgia paresthetica, 8 weeks of treatment with difelikefalin significantly improved itch intensity and increased the rate of strict complete response compared to placebo, starting as early as week 3.
1 citations
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January 2018 in “Indian journal of otolaryngology and head and neck surgery” This case study details an elderly patient with multiple nasal vestibular furunculosis leading to severe tissue damage and a nasolabial fistula, which was addressed using an alar advancement flap after allowing for tissue healing.
14 citations
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January 2014 in “Indian Journal of Dermatology Venereology and Leprology” Frontal fibrosing alopecia can affect men's beards and leads to permanent hair loss.
7 citations
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December 2023 in “International Journal of Molecular Sciences” This study demonstrated that Forsythiaside A protected against oxidative stress in both cell models and a mouse model of liver damage, suggesting its potential as a liver-protective agent.
15 citations
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November 2020 in “Pharmaceutics” In this ex vivo and mouse model study, Tofacitinib-loaded nanoparticles demonstrated enhanced delivery of the drug into hair follicles and reduced inflammatory effects compared to conventional forms, indicating potential for safer, topical use in treating alopecia areata.
June 2026 in “Frontiers in Medicine” This study evaluated the 308-nm excimer laser as an adjuvant treatment for frontal fibrosing alopecia and found it may stabilize hairline recession and improve erythema and perifollicular hyperkeratosis, with transient erythema as the only reported adverse effect.
9 citations
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April 2018 in “Journal of Dermatological Treatment” This study found that oral tofacitinib monotherapy improved nail changes in 73.3% of adults with moderate-to-severe alopecia areata over a median period of 5 months, but nail improvement was not linked to the severity of hair loss or hair regrowth.
December 2025 in “Fertility and Sterility” Both LNG-IUD and systemic progestins are effective for fertility-sparing treatment, but close monitoring is needed due to recurrence risk.
September 2023 in “Journal of the American Academy of Dermatology” This study examined the application of new clinical guidelines for diagnosing frontal fibrosing alopecia in 18 men, highlighting that current diagnostic criteria may often overlook early beard involvement and sideburn recession.
September 2017 in “Journal of Investigative Dermatology” This study found that certain circulating miRNAs in skin and plasma may serve as potential biomarkers for distinguishing frontal fibrosing alopecia from control cases, highlighting the need for further validation in larger cohorts.
20 citations
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January 2016 in “Intractable & Rare Diseases Research” In this clinical experience, treating frontal fibrosing alopecia with oral finasteride, hydroxychloroquine, tacrolimus, and excimer laser was associated with optimal results in patients with active inflammation.
October 2024 in “Benha Journal of Applied Sciences” This study of fifty female patients with frontal fibrosing alopecia in Egypt found that it is a complex condition with no definitive treatment, as it often co-occurs with lichen planus and thyroid issues.
December 2025 in “Clinical Cosmetic and Investigational Dermatology” In this report, a unique female presentation of IFAP syndrome is described, featuring musculoskeletal contractures but no photophobia, highlighting the importance of early detection and multidisciplinary care to improve outcomes and prevent disability.
March 2023 in “PARIPEX INDIAN JOURNAL OF RESEARCH” This study found that prolonged tofacitinib treatment in adult Indian patients with moderate-to-severe alopecia areata was associated with a high regrowth rate, which varied with factors like age at disease onset and treatment duration.
11 citations
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May 2023 in “Journal of Cutaneous Medicine and Surgery” This study found that combining plasma rich in growth factors with conventional treatment significantly improved hair regrowth and reduced symptoms in patients with frontal fibrosing alopecia compared to conventional treatment alone.
1 citations
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January 2020 This study found that Ift20 is essential for hair follicle stem cell identity and hair regrowth, and it regulates keratinocyte migration during wound healing through focal adhesion integrin recycling, independently of ciliogenesis.
2 citations
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January 2016 in “Dermatology online journal” This case report describes a 46-year-old man diagnosed with frontal fibrosing alopecia, a condition primarily affecting postmenopausal women, highlighting its rare occurrence in men.