Frontal Fibrosing Alopecia

August 2015 in “ Dermatología Argentina ”

María Eugenia Cappetta, María Inés Hernández, Lucía Fiesta, Julieta Arbat, Fernando Stengel

frontal fibrosing alopecia lymphocytic cicatricial alopecia scarring alopecia topical steroids intralesional triamcinolone acetonide doxycycline 5-alpha reductase inhibitors methotrexate oral lichen planus vulvar lichen planus FFA steroid creams triamcinolone injections antibiotics 5-ARI immunosuppressants

TLDR Frontal fibrosing alopecia causes hairline recession and eyebrow loss in postmenopausal women.

Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia characterized by progressive frontotemporal hairline recession. A retrospective review of 18 postmenopausal women diagnosed with FFA between June 1, 2008, and June 1, 2014, revealed an average age of 69 years. All patients exhibited frontotemporal recession with scarring alopecia, and 16 experienced partial or complete eyebrow loss. Additional findings included non-inflammatory skin-colored papules on the face in one patient, oral lichen planus in one, and vulvar lichen planus in two. Treatments administered were topical steroids, intralesional triamcinolone acetonide, doxycycline, 5-alpha reductase inhibitors, and methotrexate.

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Research cited in this study

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research Scarring Alopecia Associated With the Epidermal Growth Factor Receptor Inhibitor Erlotinib

32 citations , April 2011 in “Journal of the American Academy of Dermatology”

Erlotinib may cause scarring hair loss.

research Frontal Fibrosing Alopecia: A Clinical Review of 36 Patients

159 citations , August 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

Hydroxychloroquine effectively reduces symptoms of frontal fibrosing alopecia, especially in the first 6 months.

research Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

170 citations , December 2009 in “Histopathology”

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

research Treatment of Postmenopausal Frontal Fibrosing Alopecia with Oral Dutasteride

64 citations , June 2009 in “Journal of The American Academy of Dermatology”

Oral dutasteride can potentially treat frontal fibrosing alopecia in postmenopausal women, with some patients showing disease arrest and hair regrowth.

research Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis

155 citations , September 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

FFA is more common in postmenopausal women, can affect younger women, and may stabilize over time.

research Vertical vs. Transverse Sections in Alopecia Biopsy Diagnosis

33 citations , August 2005 in “The American Journal of Dermatopathology”

Both vertical and transverse sections are useful for diagnosing alopecia, but using both methods together is best.

research Postmenopausal Frontal Fibrosing Alopecia

57 citations , January 2003 in “Clinical and experimental dermatology”

Postmenopausal frontal fibrosing alopecia is a type of hair loss in postmenopausal women that may stop on its own but has no effective treatment.

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