Therapeutic Updates on Lichen Planopilaris and Frontal Fibrosing Alopecia: A Systematic Review

    September 2018
    Behnoush Bakhshoudeh, Maryam Salehi, Ramin Sadeghi, Alireza Omranzadeh, Toktam Sahranavard, Soheil Arekhi, Ali Jafarzadeh Esfehani, Nona Zabolinejad
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    TLDR Antimalarial agents are effective for LPP, and intralesional steroids are effective for FFA.
    This systematic review updated the treatment options for Lichen planopilaris (LPP) and Frontal Fibrosing Alopecia (FFA) by analyzing 38 studies published between March 2012 and June 2017. The review found that antimalarial agents and pioglitazone improved LPP in 73% and 71% of patients, respectively. Topical steroids and Tacrolimus/Pimecrolimus showed improvement and stabilization in about one-third and 50% of LPP cases, respectively. For FFA, antimalarial agents improved 68% of cases, intralesional steroids 83%, finasteride 100%, and dutasteride 95%. The review concluded that antimalarial agents were more effective than steroids for LPP, while intralesional steroids were more effective than antimalarial agents for FFA. However, the low quality and heterogeneity of the studies limited the ability to establish a definitive treatment protocol.
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      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 8 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.
      Diffuse hair loss and scalp biopsies

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      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 2 weeks ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community I tried salt water to stop the DHT itch

      in Treatment  60 upvotes 1 year ago
      Treating the itch associated with male pattern baldness, which is believed to be caused by DHT. Potential treatments discussed include salt water, finasteride, ketoconazole, and RU58841.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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