Use of Tofacitinib in Difficult to Treat Clinically Amyopathic Dermatomyositis

    September 2022 in “ XXXIX Congresso Brasileiro de Reumatologia ”
    Andreas Funke
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    TLDR Tofacitinib may effectively treat skin symptoms in difficult cases of dermatomyositis.
    Clinically amyopathic dermatomyositis, characterized by skin symptoms without muscle involvement, can significantly impair quality of life and is often resistant to conventional treatments. A case report of a 42-year-old woman with this condition, who did not respond to multiple systemic therapies, showed that treatment with tofacitinib 5 mg twice daily led to significant improvement in skin lesions and hair regrowth within 2 months, without notable adverse effects. This suggests that JAK inhibitors like tofacitinib may be a viable option when other treatments fail.
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      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

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      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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      in Product  1 upvotes 3 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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