Use of Tofacitinib in Difficult to Treat Clinically Amyopathic Dermatomyositis

September 2022 in “ XXXIX Congresso Brasileiro de Reumatologia ”

Andreas Funke

tofacitinib clinically amyopathic dermatomyositis JAK inhibitors skin lesions hair regrowth Xeljanz

TLDR Tofacitinib may effectively treat skin symptoms in difficult cases of dermatomyositis.

Clinically amyopathic dermatomyositis, characterized by skin symptoms without muscle involvement, can significantly impair quality of life and is often resistant to conventional treatments. A case report of a 42-year-old woman with this condition, who did not respond to multiple systemic therapies, showed that treatment with tofacitinib 5 mg twice daily led to significant improvement in skin lesions and hair regrowth within 2 months, without notable adverse effects. This suggests that JAK inhibitors like tofacitinib may be a viable option when other treatments fail.

View this study on reumatologia.org.br →

Discuss this study in the Community →

Related Community Posts Join

6 / 6 results

community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community Finasteride and Oral Minoxidil in Turkey - what I’ve found out

in Finasteride/Dutasteride 10 upvotes 4 months ago

Finasteride is available in Turkey without a prescription, with 1mg tablets costing 800 Turkish lira and 5mg tablets costing 150 lira. Oral minoxidil capsules were found at Cerrahpaşa nur eczanesi, also without a prescription.

community 22F. Should I even bother getting a biopsy? Is there any point?

7 upvotes 8 years ago

A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

community No hair, don't care! [24/F] :)

61 upvotes 8 years ago

A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 2 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

in Progress Pictures 290 upvotes 4 months ago

The conversation discusses the severe shedding caused by Minoxidil, with users sharing their experiences and outcomes. Some report eventual regrowth, while others see no improvement or worsening hair loss.

Similar Research

5 / 688 results

research Unmet Medical Needs in Chronic, Non-Communicable Inflammatory Skin Diseases

59 citations, June 2022 in “Frontiers in medicine”

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

research Good Efficacy Achieved by Baricitinib in the Treatment of Anti-MDA5 Antibody-Positive Dermatomyositis with Alopecia Areata

3 citations, February 2022 in “Rheumatology”

Baricitinib was effective in treating a patient with dermatomyositis and hair loss.

Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases