Forsythiaside A Activates AMP-Activated Protein Kinase and Regulates Oxidative Stress via Nrf2 Signaling
December 2023
in “
International Journal of Molecular Sciences
”
TLDR Forsythiaside A helps protect cells and liver from damage by reducing oxidative stress and boosting antioxidants.
Forsythiaside A (FA), derived from Forsythia suspensa, exhibits protective effects against oxidative stress by activating AMP-activated protein kinase (AMPK) and modulating the Nrf2 signaling pathway. In HepG2 cells, FA reduces apoptosis and mitochondrial dysfunction caused by arachidonic acid and iron, enhancing cell viability and decreasing reactive oxygen species (ROS) production. It also upregulates antioxidant enzymes through the ERK-AMPK-Nrf2 pathway. In vivo studies in mice show that FA reduces liver damage from carbon tetrachloride exposure, indicating its potential as an antioxidant therapeutic agent for liver protection.
