Forsythiaside A (FA), derived from Forsythia suspensa, exhibits protective effects against oxidative stress by activating AMP-activated protein kinase (AMPK) and modulating the Nrf2 signaling pathway. In HepG2 cells, FA reduces apoptosis and mitochondrial dysfunction caused by arachidonic acid and iron, enhancing cell viability and decreasing reactive oxygen species (ROS) production. It also upregulates antioxidant enzymes through the ERK-AMPK-Nrf2 pathway. In vivo studies in mice show that FA reduces liver damage from carbon tetrachloride exposure, indicating its potential as an antioxidant therapeutic agent for liver protection.
24 citations
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February 2023 in “BMC Complementary Medicine and Therapies” 
12 citations
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May 2019 in “Molecular Medicine Reports” Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.
26 citations
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March 2015 in “Phytotherapy Research” Forsythiaside-A, a natural substance, can protect against hair loss and is more effective than current treatments, potentially making it a good option for hair loss treatment.
25 citations
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August 2015 in “International Journal of Cosmetic Science” Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.
76 citations
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August 2018 in “International Journal of Cosmetic Science” Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
26 citations
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March 2015 in “Phytotherapy Research” Forsythiaside-A, a natural substance, can protect against hair loss and is more effective than current treatments, potentially making it a good option for hair loss treatment.
24 citations
,
February 2023 in “BMC Complementary Medicine and Therapies” 12 citations
,
May 2019 in “Molecular Medicine Reports” Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.
