Forsythiaside A Ameliorates Sepsis-Induced Acute Kidney Injury via Anti-Inflammation and Antiapoptotic Effects by Regulating Endoplasmic Reticulum Stress
February 2023
in “
BMC Complementary Medicine and Therapies
”
TLDR Forsythiaside A reduces kidney damage from sepsis by lowering inflammation and cell death.
The study explores the effects of Forsythiaside A (FTA) on sepsis-induced acute kidney injury (AKI) in male C57BL/6 mice, revealing that FTA significantly reduces kidney damage by lowering serum blood urea nitrogen (BUN) and creatinine levels. FTA exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines IL-1β, IL-6, and TNF-α, and demonstrates antiapoptotic properties by reducing cell apoptosis in the kidney. Mechanistically, FTA mitigates endoplasmic reticulum (ER) stress responses by regulating PERK signaling pathways, suggesting its potential as a therapeutic agent for sepsis-induced AKI.
