44 citations
,
September 1948 in “Radiology” This article reports that hypervitaminosis A in both experimental rats and children leads to severe symptoms such as weight loss, bone issues, and skin problems, which resolve upon stopping vitamin A intake.
28 citations
,
March 1986 in “The American journal of medicine” This study presented two cases of chronic hypervitaminosis A in adults, highlighting the first reported instance of hepatic cirrhosis due to long-term beef liver consumption.
24 citations
,
July 1979 in “Archives of Dermatology” This article discusses the potential for hypervitaminosis A in patients with chronic renal disease undergoing dialysis, highlighting the risks associated with low-dose vitamin A supplementation, and reports no new clinical results.
8 citations
,
August 1970 in “JAMA” This letter describes cases in which papilledema and other symptoms in young girls were attributed to hypervitaminosis A.
7 citations
,
July 1979 in “Archives of Dermatology” This article discusses the case of a patient on long-term renal dialysis with high serum vitamin A levels likely due to inadequate removal during dialysis, highlighting the need to reassess vitamin A supplementation in such patients.
1 citations
,
November 2015 in “European medical journal” This article reviews the complex role of various biological, genetic, and environmental factors in acne pathogenesis and notes no new clinical results.
15 citations
,
January 2016 in “International journal of trichology” This study found that female students experiencing diffuse hair fall had significantly lower Vitamin D3 levels compared to healthy controls.
March 2025 in “Yemeni Journal For Medical Sciences” This study found that 89.3% of female college students in Aden, Yemen, had hypovitaminosis D, with sunscreen use and lack of vitamin D supplements significantly associated with this condition.
32 citations
,
January 2006 in “Liver transplantation” This case report describes a 60-year-old male with vitamin A toxicity leading to severe liver disease and symptoms that resolved following liver transplantation, suggesting transplantation as a treatment option for noncirrhotic portal hypertension when symptoms do not improve after stopping vitamin A.
15 citations
,
May 1987 in “Fundamental and applied toxicology” This study found that SMR-2 and SMR-6, analogs of retinoic acid and retinol, were approximately 100 times more toxic than retinoic acid in mice, inducing hypervitaminosis A and affecting various organs and tissues.
7 citations
,
September 1999 in “PubMed” This study observed that consuming grouper fish liver caused symptoms similar to acute vitamin A intoxication, indicating its high vitamin A content as the likely cause.
1 citations
,
February 2022 in “Terapevtičeskij arhiv” This case report describes severe liver injury in a young patient after prolonged overuse of vitamin A, which resolved after cessation.
September 2024 in “Meditsinskiy sovet = Medical Council” This article reports a rare case of toxic keratitis in a patient due to excessive intake of vitamin A, highlighting hypervitaminosis A risks such as severe eye conditions and systemic health issues, especially with cumulative doses exceeding therapeutic levels.
January 1987 in “Toxicological sciences” In this study, SMR-2 and SMR-6, retinoid analogs, were found to be approximately 100 times more toxic than retinoic acid in male mice, primarily affecting skin, immune, and reproductive systems.
This study found that 4-(ethoxycarbophenyl) retinamide (RI) exhibited significantly lower acute, subacute, and chronic toxicity compared to other retinoids in mouse and rat models.
86 citations
,
June 2017 in “Anais Brasileiros de Dermatologia” This review discusses the role of antioxidants in managing oxidative skin damage and reports no new results, emphasizing the need for understanding their mechanisms, limitations, and risks for safe use.
97 citations
,
March 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study suggests that there is a U-shaped relationship between vitamin D hormonal forms and aging, with an optimal serum calcidiol concentration needed to minimize aging-related chronic disease risk.
January 2017 in “International Journal of Trichology” This study observed that serum Vitamin D3 levels were low among South Indian students with diffuse hair fall, highlighting global hypovitaminosis D as a concern and suggesting possible dietary or sunlight exposure influences.
May 2025 in “VETERINARY SCIENCE TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT” In this study, researchers determined that poor feed quality and nutritional deficiency, especially low vitamin A levels, were leading causes of impaired reproductive function in nutria, with deficiencies most pronounced during February-March and linked to clinical signs like growth retardation and alopecia.
September 2022 in “Ukraïnsʹkij naukovo-medičnij molodìžnij žurnal” This study found that providing quality pharmaceutical care is crucial for safe and effective use of vitamin and mineral supplements during pregnancy and breastfeeding, as many women incorrectly perceive them as entirely safe.
70 citations
,
June 2010 in “Clinics in Dermatology” This review discusses how changes in hair and skin may indicate underlying vitamin deficiencies and emphasizes the need to identify populations at risk for these deficiencies; it reports no new results.
24 citations
,
June 2010 in “Clinics in Dermatology” This review discusses various potential adverse effects of common oral vitamin and mineral supplements used in dermatology and highlights lesser-known issues like hematologic and neurologic effects from zinc.
52 citations
,
May 1982 in “The American journal of the medical sciences” This study found that the most likely cause of hypercalcemia in a patient with symptoms of hypervitaminosis A and a history of chronic vitamin A ingestion was vitamin A toxicity.
September 2024 in “Meditsinskiy sovet = Medical Council” This source reports that biotin, a water-soluble vitamin B7, may benefit skin, hair, and nail health, including various types of alopecia, without the risk of hypervitaminosis even at high doses.
October 2020 in “Our Dermatology Online” This report presents two cases where dermatologists identified internal malignancies—small cell lung cancer and stage IIB cervical cancer—through paraneoplastic skin manifestations.
5 citations
,
October 2019 in “Giornale italiano di dermatologia e venereologia” This review highlights the potential benefits of biotin in treating skin disorders related to biotin deficiency but reports no new clinical results.
October 2021 in “Journal of Advanced Biomedical and Pharmaceutical Sciences” This study reviews polycystic ovary syndrome and vitamin D, reporting no new results, and notes the involvement of vitamin D receptors and insulin in ovarian function.
7 citations
,
January 2013 in “Journal of Investigative Dermatology” This study suggests that dietary vitamin A may influence alopecia development and progression, but the mechanisms remain unclear, highlighting the interplay between genetics and nutrition in these hair loss conditions.
June 2026 in “Research Square” This study found that lower vitamin D levels were inversely associated with the severity of female pattern hair loss and patchy alopecia areata, but not with telogen effluvium.
234 citations
,
December 1996 in “Journal of The American Academy of Dermatology” The authors concluded that chronic telogen effluvium in middle-aged women presents distinct clinical and histological features that differ from androgenetic alopecia and acute telogen effluvium.