Role of Vitamin D and Insulin Resistance in Polycystic Ovary Syndrome

    October 2021 in “ Journal of Advanced Biomedical and Pharmaceutical Sciences ”
    Aya Mohammed Abdallah, Gamal A. El-Azab, Mohammed Hani Mosbeh, Hatem A. Sarhan
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    TLDR Vitamin D helps improve PCOS by aiding insulin function and ovarian health.
    Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder in women of childbearing age, affecting 10% of this population. The study covers the diagnosis, clinical symptoms, pathophysiology, hypovitaminosis D, insulin resistance, and the various methods for vitamin D and insulin assessment in relation to PCOS. The disorder is diagnosed based on androgen hypersecretion, oligo-ovulation, and/or ovarian morphologic features, with its pathophysiology involving androgen excess, neuroendocrine causes, and insulin resistance. Vitamin D has been shown to have a positive impact on PCOS and other female reproductive diseases, as it is essential for insulin regulation of steroid biosynthesis in the ovaries and follicular maturation. Furthermore, vitamin D receptors have been found in some female genital organs.
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