Preliminary Toxicity Profile of Arotinoids SMR-2 and SMR-6 in Male B6D2F1 Mice

    January 1987 in “ Toxicological sciences ”
    Charles Lindamood, Herschell D. Giles, Donald L. Hill
    TLDR SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe symptoms and organ damage in mice.
    The study investigated the preliminary toxicity of arotinoids SMR-2 and SMR-6 in male B6D2F1 mice, comparing them to retinoic acid (RA). Mice were given varying doses of these compounds, and the study was terminated on Day 57. Both SMR-2 and SMR-6 induced hypervitaminosis A symptoms (weight loss, alopecia, skin scaling, bone thinning) at mid- and high-dose levels, and were found to be approximately 100 times more toxic than RA based on weight loss. Elevated white blood cell counts and microscopic lesions in various organs were observed in the SMR groups. The study concluded that immune stimulation might be an early response to retinoids, with skin, leukopoietic tissues, reproductive organs, stomach, and bone being primary targets for toxicity.
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