A Comparison of the Toxicities of 4-(Ethoxycarbophenyl) Retinamide and Some Other Retinoids

The study compared the toxicities of 4-(ethoxycarbophenyl) retinamide (RI) and other retinoids, revealing that RI exhibited significantly lower toxicity. In acute toxicity tests, retinoic acid caused CNS toxicity, hair loss, and death in mice, while RI did not. Subacute tests showed that retinoic acid and other retinoids caused hypervitaminosis A symptoms, but RI did not. Chronic toxicity studies in mice and dogs confirmed that RI had much lower toxicity, with only occasional anorexia observed. Overall, RI demonstrated low acute, subacute, and chronic toxicity compared to other retinoids.