TLDR Retinoids can cause skin issues and hair loss due to their effects on cell membranes.
The document discussed the clinical toxicity of retinoids, highlighting that variations in their efficacy and toxicity were partly due to differences in pharmacokinetics. Retinoids were used in treating dermatologic, preneoplastic, and neoplastic diseases, with the selection of a compound based on its toxicity spectrum and study type. Reports of retinoid toxicity were common in dermatologic literature, particularly concerning acne treatment. Acute toxicity often involved skin and adnexa, with diffuse hair loss occurring in 10 to 75% of users of etretinate, acitretin, and isotretinoin. The toxicity mechanism was linked to vitamin A's effect on increasing the lability of biological membranes and its membranolytic properties.
21 citations
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June 1990 in “British Journal of Dermatology” Systemic retinoids are effective for psoriasis but have side effects; benefits may outweigh risks, especially when reducing cancer risks from other treatments.
6 citations
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September 2012 in “Our Dermatology Online” Retinoids are effective for various skin conditions and hair loss but have serious side effects, so low doses are recommended.
Proretinal nanoparticles are a safe and effective way to deliver retinal to the skin.
November 2019 in “Harper's Textbook of Pediatric Dermatology” Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.
12 citations
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January 2011 in “Dermatologic Surgery” Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” Retinoids are effective for skin conditions like severe acne and psoriasis but must be used with caution due to potential side effects and risks during pregnancy.
