Retinoids for Chemoprophylaxis of Nonmelanoma Skin Cancer

    January 2011 in “ Dermatologic Surgery ”
    David Carr, Julian Trevino, Heidi B. Donnelly
    Image of study
    TLDR Retinoids can prevent skin cancer in high-risk people but have side effects and require more research on dosing and effectiveness.
    The document reviews the effectiveness of retinoids in preventing nonmelanoma skin cancer (NMSC) in high-risk populations, including organ transplant recipients (OTRs) and individuals with certain medical conditions or genetic syndromes. It discusses the pharmacology and mechanisms of retinoids, such as isotretinoin and acitretin, and their role in inhibiting the promotion and progression of carcinogenesis. The review includes studies with varying results: one with 11 renal transplant recipients showed fewer NMSCs with etretinate, and a trial with 19 patients found a significant reduction in SCCs with acitretin. However, a study with 525 patients did not find a significant difference in BCC or SCC occurrence between those treated with retinoids and those given a placebo. Side effects of retinoid therapy are generally mild but dose-related, and include mucocutaneous effects and laboratory abnormalities. The document concludes that while systemic retinoids are effective in preventing NMSC in high-risk groups, their toxicity can be limiting, and more research is needed to determine optimal dosing and efficacy.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 221 results

      community Six months of only Dermarolling

      in Progress Pictures  157 upvotes 2 years ago
      User tried dermarolling for hair loss and shared progress pictures. Some suggest adding finasteride and minoxidil, while others debate effectiveness and frequency of dermarolling.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Tretinoin can make it worse!!!

      in Chat  7 upvotes 2 years ago
      Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

      community Tretinoin+Minoxidil heavy shedding. (31M)

      in Treatment  10 upvotes 2 years ago
      A person using Minoxidil, Finasteride, Microneedling, and recently added Tretinoin is experiencing heavy shedding and thinning hair. They suspect Tretinoin has made them respond to Minoxidil and are seeking others with similar experiences.

    Similar Research

    5 / 1000+ results