Novel Drugs Targeting Retinoic Acid Receptors

    January 2005
    Rashmi Sharma, Richa Sharma, Ujala Verma, Nusrat Kreem Bhat
    Image of study
    TLDR Newer retinoid drugs are effective for skin conditions but have significant side effects.
    Retinoids, essential for various biological processes, regulated gene transcription by binding to retinoic acid receptors (RARs) and retinoid X receptors (RXRs). The discovery of receptor co-regulators advanced retinoid studies. Systemic retinoid therapy was effective for dermatological conditions but had significant side effects. First-generation retinoids like tretinoin, isotretinoin, and alitretinoin had severe toxicities, including teratogenic effects and hair loss. Second-generation retinoids, etretinate and acitretin, were used for psoriasis and other skin disorders, showing effectiveness but also causing mucocutaneous side effects. Etretinate had a long terminal half-life, while acitretin was effective in clinical trials for ichthyosis and keratinization disorders.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 139 results

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

      in Research/Science  3 upvotes 1 month ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  63 upvotes 1 year ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  737 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community I’m already DOING EVERYTHING!!!

      in Female  27 upvotes 4 years ago
      A 26 year old female dealing with hair loss who is considering treatments such as Spiro, minoxidil and finasteride. Other potential solutions mentioned are PRP treatment, a wig, and bio-identical estrogen combined with bica.

    Similar Research

    5 / 1000+ results