research The Beneficial Effects of Pumpkin (Cucurbita Pepo L.) Seed Oil for Men's Health
Pumpkin seed oil may improve prostate health, bladder control, and hair growth in men.
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research Defining MicroRNA Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients
Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.
research Reduced Serum Brain-Derived Neurotrophic Factor in Patients with First Onset Vitiligo
People with first-time vitiligo have lower levels of a certain brain protein compared to healthy individuals.
research A Herbal Formula, Comprising Panax Ginseng and Bee-Pollen, Inhibits Development of Testosterone-Induced Benign Prostatic Hyperplasia in Male Wistar Rats
A mix of Panax ginseng and bee-pollen may help prevent prostate enlargement in rats.
research Characterization of CD4+ Stem Cells of the Skin and Their Role in Skin Homeostasis and Tumorigenesis
CD4+ skin cells may be precursors to basal cell carcinoma.
research The Role of ATP-Dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity
ATP-dependent chromatin remodeling is crucial for skin development and stem cell function.
research Antioxidants and Mitochondrial Bioenergetics: Charnoly Bodies in Neurodegenerative Diseases, Cardiovascular Disorders, and Cancer
Antioxidants may help improve mitochondrial health and could be used to treat diseases related to cell damage.
research Pubertal Acne
Pubertal acne is linked to hormonal changes, affects quality of life, and is treated similarly to adult acne.
research Festschrift in Honor of the 65th Birthday of Dr. Howard I. Maibach
Antiyeast treatments work better for seborrheic dermatitis than steroids, and other findings include increased skin bacteria under plastic wrap, a nasal cell defect in Staphylococcus aureus carriers, quick resolution of certain skin reactions, high rubber latex allergy in spina bifida patients, and glyceryl monopentadecanoate's effectiveness for male hair loss.
research Reduced SMAD2/3 Activation Independently Predicts Increased Depth of Human Cutaneous Squamous Cell Carcinoma
Lower SMAD2/3 activation predicts more severe skin cancer.
research Hairy Tale of Signaling in Hair Follicle Development and Cycling
Hair growth and development are controlled by specific signaling pathways.
research Cytochrome P450: A Target for Drug Development for Skin Diseases
Modulating Cytochrome P450 activity could help develop new skin disease treatments.
research New Insights into the Role of Runx1 in Epithelial Stem Cell Biology and Pathology
Runx1 affects hair growth, cancer development, and autoimmune diseases in epithelial tissues.
research A Kindred With Mutant IKAROS and Autoimmunity
A mutation in the IKZF1 gene causes immune system overactivity, linked to autoimmune diseases like lupus.
research Hidradenitis Suppurativa: A Folliculotropic Disease of Innate Immune Barrier Dysfunction?
Hidradenitis suppurativa is a skin disease caused by the breakdown of the skin's natural immune barriers, especially around hair follicles.
research Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology
Eating fewer calories may slow skin aging and improve skin health through various biological changes.
research Connexin 30, A New Marker Of Hyperproliferative Epidermis
Connexin 30 is usually absent in normal skin but can appear in certain skin conditions.
research Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair
KGF and activin are crucial for skin healing and repair.
research Disturbed Epidermal Structure in Mice with Temporally Controlled Fatp4 Deficiency
Fatp4 is crucial for healthy skin development and function.
research Cellular and Extracellular Involvement in the Regeneration of the Rat Lower Vibrissa Follicle
Both cell and non-cell parts are important for rat whisker follicle regrowth.
research Enhancing 1α-Hydroxylase Activity with the 25-Hydroxyvitamin D-1α-Hydroxylase Gene in Cultured Human Keratinocytes and Mouse Skin
Adding a specific gene to skin cells can help treat skin disorders like psoriasis.
research Keratin Pattern in Hyperkeratotic and Ulcerated Gastric Pars Oesophagea in Pigs
Epithelial proliferation and hyperkeratosis are linked to gastric ulcers in pigs.
research Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression
Overexpression of spermidine/spermine N1-acetyltransferase (SSAT) in transgenic mice led to putrescine accumulation in the skin, resulting in permanent hair loss by 3 weeks of age, with hair follicles replaced by dermal cysts and epidermal utriculi. This condition mirrored hyperproliferative cutaneous disorders like psoriasis, characterized by delayed epidermal differentiation and altered expression of differentiation markers. Immunohistological analysis confirmed disturbed differentiation in SSAT transgenic skin, and similar changes were observed in organotypic cultures of transfected rat epidermal cells. Reducing putrescine levels through biosynthesis inhibition alleviated skin changes and allowed hair regrowth, indicating that keratinocyte differentiation disorders were responsible for the cutaneous changes in SSAT transgenic mice. This highlighted the importance of polyamine metabolism regulation in keratinocyte maturation.
research Follicles, Fungi, And Scalp Conditions
Malassezia yeast plays a key role in dandruff and seborrhoeic dermatitis.
research Cyclosporine
Cyclosporine, an immunosuppressant targeting CD4+ T lymphocytes, was found to directly affect the growth of various epithelial cell types. It stimulated hair follicle keratinocytes, causing hypertrichosis, while exerting a cytostatic effect on other epithelial cells. This antiproliferative effect was also observed in some cyclosporine analogues with minimal or no immunosuppressive properties, indicating different molecular mechanisms for epithelial cell growth modulation and immunosuppression. This discovery suggested potential for using nonimmunosuppressive cyclosporines in treating hyperproliferative epidermal diseases.
research Resolution of Plantar Hyperkeratosis of Pachyonychia Congenita During Chemotherapy for Ewing Sarcoma
Chemotherapy improved a girl's painful foot condition linked to pachyonychia congenita.
research The RATIOnal Role of Polyamines in Epidermal Differentiation
The study by Rahim et al. (2021) demonstrated that the balance of polyamine ratios, specifically the reduction of putrescine and increase of spermine regulated by AMD1, played a critical role in keratinocyte differentiation and epidermal homeostasis. This shift was essential for managing hyperproliferative skin disorders like psoriasis and skin cancer. The research suggested that activating AMD1 could be a promising therapeutic strategy, highlighting the importance of focusing on polyamine balance rather than total levels in treating these conditions.
research Circadian Rhythms on Skin Function of Hairless Rats: Light and Thermal Influences
Light and temperature affect the daily skin function rhythms in hairless rats, with temperature influencing water loss but not skin hydration.
research Glutamic Acid Promotes Hair Growth in Mice
Glutamic acid helps increase hair growth in mice.
research Androgen Effects in Mammals
Testosterone is crucial for development, growth, and various body functions in mammals.