67 citations
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January 1997 in “Lancet” This article discusses the causes of hirsutism, identifying increased androgen production and heightened skin sensitivity, and provides no new clinical results.
34 citations
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February 2012 in “International Journal of Dermatology” This study found that exogenous ochronosis from hydroquinone use in melasma treatment has distinctive dermatoscopic features that may aid in diagnosis without needing a biopsy.
June 2023 in “Journal of Natural Remedies” This study found that the methanolic extract of Hibiscus rosa sinensis exhibits promising 5α-reductase inhibitory activity, suggesting its potential use in the treatment of androgenic conditions like male pattern hair loss and benign prostatic hyperplasia.
4 citations
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December 2012 in “Arquivos Brasileiros De Endocrinologia E Metabologia” A postmenopausal woman's masculine symptoms improved after surgery for a hormone-producing ovarian tumor.
This study formulated and evaluated a Hibiscus rosa-sinensis herbal gel, identifying a 20% concentration as superior in physical properties, suggesting its potential as an alternative drug delivery system.
May 2006 in “Women's Health Medicine” This review examines the causes, assessment, and treatments of hirsutism and highlights the need for future research in managing this condition but presents no new research findings.
67 citations
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July 2006 in “Clinics in Dermatology” This review discusses the dermatologic manifestations of hyperandrogenism in women and outlines the diagnostic approach and treatment options, reporting no new clinical results.
January 2004 in “Online Publication Service of Würzburg University (Würzburg University)” This study found that women with PCOS have higher activity of the enzyme 5alpha-reductase, which may contribute to their elevated androgen levels.
5 citations
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September 2015 in “Medical hypotheses” This article suggests that a topical sulfonylurea drug may inhibit excessive hair growth caused by diazoxide without affecting its beneficial effects on beta cells, potentially offering a treatment for various forms of hypertrichosis and hirsutism.
2 citations
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May 2019 in “Journal of the American Academy of Dermatology” The correspondence discusses the higher prevalence of acne vulgaris in hidradenitis suppurativa patients, but notes potential overestimation due to unrecognized facial HS.
January 2011 in “Yearbook of Dermatology and Dermatologic Surgery” Acne and hair loss are not good indicators of hormone imbalance in PCOS, but excessive body hair is.
6 citations
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July 2013 in “Acta Clinica Belgica” This review discusses idiopathic hirsutism and suggests that combination treatment, including androgen suppression and cosmetic methods, is most effective, but notes that its pathogenesis remains unclear.
1 citations
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November 2007 in “Humana Press eBooks” This article reviews the differential diagnosis and management approaches for androgen excess disorders, highlighting the predominance of polycystic ovary syndrome as the underlying cause and reports no new clinical findings.
January 2026 in “Chemical Communications” This study found that calanthoside, a compound isolated from Calanthe species, promotes the proliferation of human hair follicle dermal papilla cells more effectively than minoxidil.
2 citations
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August 2019 in “International Journal of Applied Pharmaceutics” This study explored the use of SOD-loaded niosomes as carriers to enhance the delivery of superoxide dismutase into hair follicles on guinea pig skin, finding that niosomes improved SOD penetration and preservation compared to free SOD, suggesting their potential as effective delivery vehicles.
July 2023 in “International journal of life science and pharma research” In this study, a herbal hair cream containing extracts from Hibiscus rosa sinensis, Eclipta alba, and Solanum nigrum was developed, showing promising in-vitro inhibition of the 5α-reductase enzyme and potential benefits for alopecia treatment.
October 2025 in “Journal of the Endocrine Society” In this case study, a 68-year-old woman with hyperandrogenism and presumed ovarian origin responded well to GnRH agonist therapy, normalizing testosterone levels and stabilizing blood pressure, suggesting its effectiveness as a non-surgical treatment option.
December 2023 in “Asian Journal of Pharmaceutical Research and Development” This research suggests that phytoestrogen-rich herbal extracts may help reduce hyperandrogenism, insulin resistance, and ovarian weight while promoting ovulation in polycystic ovarian syndrome, indicating potential for discovering new bioactive compounds.
1 citations
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July 2024 in “Journal of Medical and Life Science” In this review, researchers examined the complex interaction of hormones, genes, and reactive oxygen species in hirsutism and PCOS, highlighting prolactin's role in modulating hormone levels linked to hair growth disorders.
2 citations
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August 1999 in “PubMed” September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in hidradenitis suppurativa, the proteins SERPINB3/B4 and S100A7/A8/A9 were significantly overexpressed in lesional skin compared to nonlesional skin, suggesting new pathways in the disease's pathogenesis.
This review discusses hyperandrogenism in polycystic ovary syndrome, focusing on symptoms and diagnostic criteria, but it reports no new clinical research findings.
January 2026 in “Indus journal of bioscience research.” In this study, Hibiscus rosa-sinensis extract was used to formulate and evaluate herbal cosmetic creams for their antioxidant properties, stability, and effectiveness. The formulations demonstrated strong antioxidant potential, stability under various conditions, and favorable cosmetic qualities, suggesting HRS as a beneficial ingredient in skincare products.
April 2016 in “Journal of The American Academy of Dermatology” This study found that dermatology consultations in a tertiary care center led to treatment changes in most cases, especially for complex conditions potentially linked to systemic disease.
2 citations
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October 2015 in “The New England Journal of Medicine” This case report describes a 57-year-old woman with hirsutism, hair loss, and vocal changes, who was found to have elevated testosterone levels but normal dehydroepiandrosterone sulfate levels.
22 citations
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March 2000 in “Clinical endocrinology” This study found that while ethinyl oestradiol and cyproterone acetate effectively treated hirsutism in 90% of patients, 80% experienced relapse within six months after stopping treatment, suggesting long-term use is necessary.
October 2024 in “Journal of the Endocrine Society” In this case report, a 62-year-old woman with hyperandrogenism and polycythemia was diagnosed with a rare ovarian steroid cell tumor, highlighting the importance of considering such tumors in similar presentations; surgical removal led to symptom and lab normalization.
September 2023 in “Journal of Rawalpindi Medical College/Journal Rawalpindi Medical College” This study found that oral contraceptive pills containing cyproterone acetate and drospirenone were more effective at reducing hirsutism in women with PCOS than those containing levonorgestrel over a 6-month period.
January 2013 in “Obstetrical & gynecological survey” This review discusses diagnostic and management approaches for hirsutism, emphasizing that most cases are due to polycystic ovary syndrome or obesity-related disorders, with idiopathic hirsutism often treated cosmetically.
February 2026 in “Frontiers in Medicine” This study suggests that combining LMWHA solution and HCO might improve mild to moderate urinary incontinence in women with GSM, potentially offering benefits over HA therapy alone, but further research is needed.