Topical Sulfonylurea as a Novel Therapy for Hypertrichosis Secondary to Diazoxide, and Potentially for Other Conditions with Excess Hair Growth

    September 2015 in “ Medical hypotheses ”
    Ron S. Newfield
    TLDR Topical sulfonylurea may reduce excessive hair growth caused by certain medications.
    The document discussed the potential use of topical sulfonylurea as a novel therapy for hypertrichosis, particularly when caused by diazoxide, a drug used to treat hypoglycemia. The hypothesis suggested that sulfonylurea could inhibit KATP potassium-gated channels in the skin, which control hair growth, thereby reducing excessive hair growth in a targeted manner. This approach could be beneficial for conditions like Cantú syndrome or drug-induced hypertrichosis. The significance of this hypothesis lay in its potential to offer a localized treatment for excess hair growth without the systemic side effects of current treatments. The author declared no conflicts of interest or funding related to the manuscript.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  48 upvotes 2 months ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 6 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community M18 - 7 Months on topical fin + min Not working for me

      in Finasteride/Dutasteride  90 upvotes 4 days ago
      Topical finasteride and minoxidil are not effective for the user, who is considering switching to oral treatments like finasteride or dutasteride. Many suggest oral medications are more effective, and some recommend additional treatments like microneedling and other topical solutions.

      community Topical bimatoprost or latanoprost

      in Product  11 upvotes 1 week ago
      OP is considering adding topical bimatoprost or latanoprost to their hair loss treatment, which already includes oral minoxidil, and is seeking reliable sources for these products. Users discuss the effectiveness and sourcing of these treatments, with some using bimatoprost for both hairline and eyelashes, and others planning to use latanoprost mixed with finasteride.

      community Topical latanoprost chance of eye color change?

      in Product  1 upvotes 1 week ago
      The user is using oral minoxidil for hair growth and is considering adding topical latanoprost, but is concerned about potential eye color change. They are seeking advice on the effectiveness of latanoprost for hair thickening and the risk of eye color change.

    Related Research

    1 / 1 results