Topical Sulfonylurea as a Novel Therapy for Hypertrichosis Secondary to Diazoxide, and Potentially for Other Conditions with Excess Hair Growth

    September 2015 in “ Medical hypotheses ”
    Ron S. Newfield
    TLDR Topical sulfonylurea may reduce excessive hair growth caused by certain medications.
    The document discussed the potential use of topical sulfonylurea as a novel therapy for hypertrichosis, particularly when caused by diazoxide, a drug used to treat hypoglycemia. The hypothesis suggested that sulfonylurea could inhibit KATP potassium-gated channels in the skin, which control hair growth, thereby reducing excessive hair growth in a targeted manner. This approach could be beneficial for conditions like Cantú syndrome or drug-induced hypertrichosis. The significance of this hypothesis lay in its potential to offer a localized treatment for excess hair growth without the systemic side effects of current treatments. The author declared no conflicts of interest or funding related to the manuscript.
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