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      learn Fluridil

      a topical anti-androgen with less systemic involvement

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      powerful topical and oral anti-androgen used mostly by women

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      a novel topical treatment that inhibits DHT on androgen receptors

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      a potent but unapproved and potentially problematic topical anti-androgen

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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Creatine is the opposite of minoxidil !

      in Research/Science  318 upvotes 3 weeks ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community Being Safe on Oral Minoxidil: tl;dr on the literature.

      in Research/Science  51 upvotes 10 months ago
      Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

      community How come topical finasteride even works at all?

      in Finasteride/Dutasteride  31 upvotes 1 week ago
      Topical finasteride can effectively reduce scalp DHT by targeting local enzymes, despite less systemic impact compared to oral forms. Combining oral dutasteride with topical finasteride and minoxidil may enhance hair loss prevention, though evidence of its effectiveness is limited.