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research Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth

5 citations , September 2015 in “Medical hypotheses”

This article suggests that a topical sulfonylurea drug may inhibit excessive hair growth caused by diazoxide without affecting its beneficial effects on beta cells, potentially offering a treatment for various forms of hypertrichosis and hirsutism.

research Hair growth effect of minoxidil

25 citations , January 2002 in “Folia Pharmacologica Japonica”

This article reviews the proposed mechanism of minoxidil in treating androgenetic alopecia, suggesting it may prolong the anagen phase by modulating cell growth factors and vascular activity, but reports no new results.

research Topical Minoxidil-Loaded Nanotechnology Strategies for Alopecia

22 citations , March 2020 in “Cosmetics”

This review discusses the potential of nanotechnology-based formulations for delivering topical minoxidil to improve hair loss treatment outcomes and reports no new clinical results, urging further research into their benefits and safety considerations.

research Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia

11 citations , April 2015 in “International Journal of Cosmetic Science”

This study found that topical adenosine significantly increased the ratio of thick hairs and contributed to global improvement in Japanese men with androgenetic alopecia compared to niacinamide, with no observed adverse events.

research Topical adenosine increases the proportion of thick hair in Caucasian men with androgenetic alopecia

10 citations , October 2015 in “Journal of Dermatology”

This study found that adenosine significantly increased the proportion of thick hair in Caucasian men with androgenetic alopecia, with no reported adverse effects.

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Community Join

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community 5 months oral 1.2mg Fin, 3mg Min. Switching to Dut. 39M

in Progress Pictures 13 upvotes 9 months ago

The user has been using oral finasteride and minoxidil for five months with some progress and plans to switch to dutasteride, while also considering a hair transplant for better coverage. Suggestions include adding microneedling, Nizoral shampoo, and possibly using both oral and topical treatments for improved results.

community deeper understanding of microneedling

16 upvotes 3 years ago

Microneedling can enhance hair growth by increasing drug absorption and activating stem cells, with different needle depths serving distinct purposes. Users report success with microneedling, often in combination with treatments like minoxidil and finasteride, and emphasize waiting periods for topical application to avoid side effects.

community Creatine is the opposite of minoxidil !

324 upvotes 11 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Being Safe on Oral Minoxidil: tl;dr on the literature.

51 upvotes 1 year ago

Oral minoxidil is effective for hair loss but can cause cardiovascular side effects, such as pericardial effusion, especially in those with genetic predispositions. Starting with low doses and monitoring cardiovascular health are advised to reduce risks.

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Learn

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learn Finasteride

Topical or oral? Choosing between pills and lotions according to your case. In studies, topical finasteride gave much lower blood levels of the drug than tablets but still lowered blood DHT, and whether it causes fewer side effects has not been established. There is no FDA-approved topical finasteride, and the FDA warned about compounded versions in April 2025.

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

learn Vitamin B12

Can topical products containing Vitamin B12 improve scalp health and hair growth? Topical Vitamin B12 may not significantly improve hair growth unless there's a deficiency.

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