Topical Hyaluronic Acid and Oxygen for Urinary Incontinence: A Double-Center Retrospective Study

    February 2026 in “ Frontiers in Medicine ”
    Paolo Manna, Basilio Pecorino, Fabiola Perrone, Marika Di Blasi, Paolo Scollo, Giuseppe Scibilia, Fulvio Zullo
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    TLDR Combining hyaluronic acid and oxygen may help improve urinary incontinence in menopausal women.
    The study suggests that a combination of low molecular weight hyaluronic acid (LMWHA) solution and hyperbaric oxygen (HCO) may improve mild and moderate stress and mixed urinary incontinence in women with genitourinary syndrome of menopause (GSM), showing potential superiority over hyaluronic acid (HA) therapy alone. However, the authors emphasize the need for further studies with a controlled design and a larger population to confirm these findings.
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