Cutaneous Xanthomas in Homozygous Familial Hypercholesterolemia: A 12-Year Follow-Up

    April 2016 in “ Journal of The American Academy of Dermatology ”
    Image of study
    TLDR Women with PCOS often have hirsutism and skin changes, which indicate a need for metabolic health checks.
    The document reports on a retrospective cross-sectional study conducted at the University of California San Francisco (UCSF) PCOS Multidisciplinary Clinic, which examined the cutaneous and systemic features of polycystic ovary syndrome (PCOS) in a racially diverse sample of 401 women referred for suspected PCOS over a 6-year period. The study found that women who met the Rotterdam PCOS diagnostic criteria had significantly higher rates of hirsutism, acne, and acanthosis nigricans (AN) compared to those who did not meet the criteria. Hirsutism and AN were associated with elevated free testosterone levels and metabolic abnormalities such as insulin resistance, dyslipidemia, and elevated body mass index (BMI). The study concluded that hirsutism and AN are reliable cutaneous markers of PCOS and should prompt further diagnostic evaluation for metabolic comorbidities. Acne and androgenic alopecia (AGA), however, were not reliable markers of biochemical hyperandrogenism in this population. The study emphasizes the importance of a comprehensive skin exam in diagnosing PCOS and its associated risks.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 25 results

      community AA and Hirsutism but T levels are normal

      in Female  8 upvotes 3 years ago
      27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

      community Finasteride 5mg & Spironolactone 100mg

      in Female  2 upvotes 3 weeks ago
      A 20-year-old female is using finasteride 5mg and spironolactone 100mg for severe hirsutism and is experiencing minor side effects like water weight loss and irregular periods. She is concerned about potential future side effects and hair regrowth on her scalp.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  105 upvotes 3 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

      community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025

      in Treatment  118 upvotes 3 months ago
      Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.

      community Does low HGH leading to hairloss?

      in Research/Science  12 upvotes 10 months ago
      The user experiencing diffuse hair loss is using various treatments including RU58841, finasteride, minoxidil with tretinoin, anti-hair loss shampoo, and microneedling, and is considering adding peptides TB500, BPC157, and GHK-Cu. They have low growth hormone levels and are questioning its impact on hair loss, while another user suggests androgenic alopecia and androgens are likely the main cause of hair loss.

    Similar Research

    6 / 1000+ results