Efficacy of Cyproterone Acetate and Drospirenone Containing Oral Contraceptive Pills in Treatment of Hirsutism in Patients With Polycystic Ovary Syndrome

September 2023 in “ Journal of Rawalpindi Medical College/Journal Rawalpindi Medical College ”

Nurain Baig Mughal Maria Sarfraz, Hina Akram, Afroza Abbas, Sadaf Shaheen, Rameez Zafar, Eesha Yaqoob

cyproterone acetate drosperinone oral contraceptive pills hirsutism polycystic ovary syndrome PCOS Ferriman-Gallwey score levonorgestrel OCPs birth control pills

Studysummary This study found that oral contraceptive pills containing cyproterone acetate and drospirenone were more effective at reducing hirsutism in women with PCOS than those containing levonorgestrel over a 6-month period. Our plain-language summary of this paper — not a Tressless recommendation.

The study investigated the effectiveness of oral contraceptive pills (OCPs) containing cyproterone acetate and drosperinone in treating hirsutism in patients with polycystic ovary syndrome (PCOS). It included 80 participants, with 40 in the intervention group receiving the OCPs and 40 in the control group receiving a placebo for 6 months. The efficacy was measured using the Ferriman-Gallwey score before and after treatment. The results showed that the OCPs with cyproterone acetate and drosperinone were more effective in reducing hirsutism than those containing levonorgestrel. However, the conclusion emphasizes that OCPs may not be suitable for all women with PCOS and the potential risks and benefits should be discussed with a healthcare professional.

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Research cited in this study

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Clinical, Hormonal and Metabolic Parameters in Women With PCOS Using Different Combined Oral Contraceptives (Containing Chlormadinone Acetate Versus Drospirenone)

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American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

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This review outlines the challenges in diagnosing hyperandrogenism in women, focusing on its manifestations like hirsutism, acne, and virilization, but provides no new results.

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