January 2021 in “Research Square (Research Square)” This study observed that combining PRP with pro-angiogenic cells (Angio PRP) enhanced wound healing in a mouse model by promoting keratinocyte proliferation, angiogenesis, and vessel remodeling.
24 citations
,
January 2019 in “Biomaterials Science” This study demonstrated that a bio-3D printed artificial skin scaffold, seeded with adipose-derived mesenchymal stem cells, showed promising wound healing properties by enhancing cell recruitment, migration, and gene expression related to tissue regeneration.
128 citations
,
March 1996 in “Journal of Investigative Dermatology” Increased IGF-1R expression is linked to thicker skin growth.
1 citations
,
January 2024 in “Fibrosis” This review examines advancements in hydrogel formulations aimed at preventing dermal fibrosis and promoting scarless wound healing, highlighting their role in regulating myofibroblast differentiation and controlling the wound microenvironment.
March 2022 in “Benha Journal of Applied Sciences” This study found that serum PGRN levels and HOMA-IR were significantly higher in male AGA patients compared to controls, suggesting a link to insulin resistance and metabolic syndrome.
23 citations
,
July 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.
December 2024 in “ACS Applied Materials & Interfaces” In this study, dynamic hyaluronic acid hydrogels with properties like injectability and controlled degradation were developed to enhance healing and remodeling of diabetic wounds, achieving effects such as inflammation reduction, increased angiogenesis, and neovascularization, leading to complete wound healing.
2 citations
,
January 2024 in “Proceedings of the National Academy of Sciences of the United States of America” This study developed a multiscale spatial atlas of healthy skin and basal cell carcinoma, revealing a hair follicle origin for BCC and the expansion of specific cell populations such as POSTN+ fibroblasts and RGS5+ pericytes, suggesting roles in skin cancer stroma expansion and vascular remodeling.
16 citations
,
January 2025 in “Burns & Trauma” This review highlights the promising potential of using nanomedicine-based immunotherapy in tissue regeneration, detailing recent advances in nanocomposite biomaterials and the modulation of immune responses to create optimal environments for tissue repair.
39 citations
,
April 1992 in “Development” In this study, researchers detailed how hair follicles regenerate after microsurgical amputation, observing a wound reaction involving dynamic dermal-epidermal interactions and changes in extracellular matrix components.
February 2026 in “Colloids and Surfaces B Biointerfaces” The composite dressing improved wound healing and hair growth in mice.
3 citations
,
December 2025 in “Biomaterials Research” In this study, researchers developed a new hydrogel incorporating fibroblast growth factor 21 that improved wound healing in diabetic mice by reducing inflammation and enhancing skin repair, suggesting strong potential for future clinical application in diabetic wound management.
128 citations
,
August 2020 in “Cell stem cell” In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.
4 citations
,
October 2024 in “Tissue Engineering and Regenerative Medicine”
This review discusses recent research on the cell sources and signaling pathways involved in wound-induced hair follicle neogenesis, noting its complexity and association with immune responses, but reports no new experimental findings.
October 2021 in “Austin journal of biomedical engineering” In this study, researchers modified an acellular scaffold with different concentrations of eggshell membrane protein, finding that a 5% concentration effectively enhanced tissue regeneration in mice with excisional wounds, achieving complete healing within 14 days without causing immunogenicity or inflammation.
April 2018 in “Plastic & Reconstructive Surgery Global Open” This study successfully isolated LGR6+ epithelial stem cells from rats and demonstrated their multipotency, suggesting potential for fracture healing research.
7 citations
,
June 2020 in “JAAD Case Reports” This article reviews the development of biocompatible artificial hair for treating hair loss and reports encouraging results from clinical trials, but it provides no new clinical findings.
68 citations
,
August 2014 in “Stem Cells Translational Medicine” This study found that composite skin constructs containing dermal papilla cells promoted better skin healing and hair regeneration in nude mice, highlighting their role in tissue-engineered skin for severe injuries.
11 citations
,
June 1974 in “Journal of Cutaneous Pathology” In this study, electron microscopy of follicular mucinosis showed severe cytoplasmic degeneration in hair follicles, with myelin figures and onion-like lamellar structures, but no indications of mucin release through degeneration or degradation were found.
46 citations
,
July 2015 in “Wound repair and regeneration” This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.
2 citations
,
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that a specific Gli1+ subpopulation in the perivascular niche plays a crucial role in wound healing by differentiating into myofibroblasts, with their genetic ablation impairing wound repair.
October 2024 in “Journal of Cutaneous Immunology and Allergy” This case report describes a successful treatment of sarcoidal foreign body reactions caused by permanent makeup ink with local steroid injections, while also identifying the involvement of M2 macrophages in the reaction.
August 2026 in “Cellular and Molecular Life Sciences” This study investigated the role of the glycoprotein Thy-1 in hypertrophic scar formation using a murine model, finding that Thy-1 knockdown reduced scar size and encouraged functional regeneration by influencing the p38MAPK signaling pathway under high-tension conditions.
June 2025 in “American Journal of Dermatopathology” This case report describes a rare instance of sarcoidal granulomatous alopecia areata in a 42-year-old man, with histopathological findings suggesting inflammation but ruling out causes like tuberculosis and syphilis, resulting in treatment with tofacitinib.
February 2025 in “Theranostics” In this study, researchers used 3D bioprinting with skin stem cells and specific hydrogels to create artificial skin that successfully promoted complete wound healing and the regeneration of skin structures, including hair follicles and blood vessels, in mice.
November 2022 in “Regenerative Therapy” This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.
2 citations
,
December 2015 in “Journal of dermatology” This letter to the editor discusses excessive hair growth observed around local β-interferon injection sites for malignant melanoma but reports no new clinical results.
22 citations
,
August 2020 in “Cells” This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.
4 citations
,
October 2023 in “Case Reports in Dermatology” In this case report, the researchers highlighted the diagnostic challenge of Majocchi’s granuloma, a deep fungal infection that mimics other skin conditions and resists initial treatment, emphasizing the importance of considering it as a diagnosis even after failed topical antifungal therapies.