This report describes a complex case of postmenopausal hyperandrogenism with virilization and concurrent rare ovarian tumors, highlighting the critical role of interdisciplinary collaboration in diagnosing and managing such challenging scenarios.
November 2023 in “International journal of reproduction, contraception, obstetrics and gynecology” This review discusses the hypotheses surrounding the developmental origins of polycystic ovary syndrome, particularly the role of prenatal androgen exposure, and reports no new experimental results.
October 2023 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that in women with PCOS, insulin resistance is closely associated with hyperandrogenism, indicating it may independently predict increased androgen levels.
October 2023 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This review found that hyperandrogenism in premenopausal women is linked to a higher prevalence of cardiovascular risk factors and diseases regardless of obesity, while in postmenopausal women, these risks depend on obesity.
September 2023 in “Research Square (Research Square)” In this study, overweight women with polycystic ovarian syndrome who took evening primrose oil for 10 weeks experienced significant reductions in BMI, LDL, and total cholesterol levels, alongside hormonal changes such as decreased LH, FSH, and testosterone levels, and increased estrogen.
January 2023 in “Case Reports in Obstetrics and Gynecology” This case report highlights the need for early diagnosis and treatment of ovarian hyperthecosis to enhance the quality of life and health outcomes for affected patients.
This study found that while iron depletion through phlebotomies is safe for women with functional ovarian hyperandrogenism, it does not improve their cardio-metabolic profile and may reduce non-enzymatic antioxidant capacity.
November 2022 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses the causes and recommended clinical investigations for postmenopausal hyperandrogenism, highlighting the role of androgen excess in symptoms like hirsutism and its association with metabolic disorders.
November 2022 in “Scientific Reports” This study found that ESR1 gene polymorphisms may be linked to hormonal imbalances in young women with hyperandrogenism, potentially affecting bone mineral density indirectly.
February 2021 in “Endocrinology, diabetes & metabolism case reports” This case report describes a postmenopausal woman with hirsutism and hair loss attributed to ovarian stromal hyperplasia; surgical removal of the ovaries normalized testosterone levels and resolved symptoms.
January 2021 in “Case Reports” This case study reports a rare instance of mucinous cystadenoma causing severe virilization in a postmenopausal woman, highlighting a possible link with rapidly progressive hyperandrogenism.
September 2020 in “Fertility and sterility” In this study, there was no significant difference in blastocyst quality scores between hyperandrogenic and classical PCOS patients undergoing IVF, suggesting other factors might influence the lower embryo utilization in hyperandrogenic cases.
June 2020 in “AACE clinical case reports” This case report illustrates that Leydig cell tumors, despite causing significantly elevated androgen levels, can be difficult to localize due to their small size, as demonstrated in a 42-year-old woman whose tumor was only identified after oophorectomy.
September 2016 in “Gynecology Obstetrics and Reproductive Medicine” This review outlines the diagnostic criteria and management strategies for polycystic ovary syndrome, focusing on hyperandrogenism's cutaneous manifestations, such as hirsutism and acne, and describes treatments like oral contraceptives and antiandrogens to address these issues.
January 2015 in “International Journal of Research in Medical Sciences” This case report is the first to associate HAIR-AN syndrome with polycystic ovaries, Hashimoto’s thyroiditis, and several metabolic conditions in a 21-year-old woman, emphasizing early diagnosis and management.
November 1993 in “PubMed” This article reviews the role of androgens in skin metabolism and diseases like acne and androgenic alopecia, but reports no new clinical results; the authors note unresolved issues regarding androgen interactions in skin structures.
92 citations
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October 2002 in “Journal of The American Academy of Dermatology” This study reports that oral finasteride improved or stabilized hair loss in women with hyperandrogenism but not in postmenopausal women with female pattern hair loss.
84 citations
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September 2014 in “European journal of endocrinology” This review examines the causes and characteristics of androgen excess in postmenopausal women, but reports no new clinical results; the authors emphasize challenges in diagnosis and potential long-term health impacts.
67 citations
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February 2010 in “Acta Obstetricia et Gynecologica Scandinavica” In this study, hirsutism in women with PCOS was strongly associated with hyperandrogenism and metabolic abnormalities, while acne and androgenic alopecia were not effective markers for hyperandrogenism.
36 citations
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February 2021 in “Clinical Nutrition” This study found that resveratrol improved menstrual regularity and reduced hair loss in women with PCOS, but did not affect androgen levels or metabolic profiles.
36 citations
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May 2011 in “The Journal of Clinical Endocrinology & Metabolism” Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.
30 citations
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January 2015 in “BioMed Research International” Continuous light exposure in rats leads to PCOS-like symptoms and suggests sleep habits might affect the disorder's development.
25 citations
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August 1989 in “Seminars in reproductive medicine” This article discusses the use of oral contraceptives for treating hyperandrogenism in women, reporting improvement in most patients, especially in reducing new hair growth, but presents no new clinical findings.
20 citations
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January 1998 in “Dermatology” This report highlights a case of acne neonatorum in a newborn boy, linking it to familial hyperandrogenism, and emphasizing the importance of family history and maternal hyperandrogenism in diagnosis.
19 citations
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January 2017 in “Hormone Molecular Biology and Clinical Investigation” This study found a high prevalence of hyperandrogenemia in women with PCOS, with distinct biochemical differences according to BMI and presence of hyperandrogenemia.
17 citations
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December 2021 in “Reproductive Biology and Endocrinology” This study found that statin treatment significantly reduced androgen levels and improved symptoms of hyperandrogenism, such as hirsutism and acne, in women with polycystic ovary syndrome.
17 citations
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April 2010 in “Archives of Gynecology and Obstetrics” This study found that obese Taiwanese women had a lower incidence of acne than non-obese women, despite having higher serum testosterone levels.
17 citations
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January 1984 in “Psychotherapy and psychosomatics” This study reported that 44% of hirsute women undergoing cyproterone acetate treatment experienced impaired sexual enjoyment, highlighting the need to inform patients about potential side effects.
11 citations
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August 2019 in “The Journal of Sexual Medicine” This study found that women with nonclassic congenital adrenal hyperplasia (NC-CAH) reported lower sexual function and higher sexual distress compared to those with classic CAH (C-CAH), particularly among those showing signs of androgen excess.
11 citations
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August 2014 in “PubMed” This study found that women with acne had higher rates of hyperandrogenism and obesity, and higher androgen levels and BMI were linked to increased acne severity.