1 citations
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November 2024 in “Diabetes Metabolic Syndrome and Obesity” In this study, researchers found that a specific genetic variant in the INSR gene is linked to severe insulin resistance and hyperandrogenemia in type A insulin resistance syndrome, suggesting the benefit of exon sequencing for accurate diagnosis and treatment.
1 citations
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July 2022 in “BMC Women s Health” This report describes a rare case of elevated serum DHEAS levels in a postmenopausal woman, linked to an ovarian sex cord-stromal tumor rather than the adrenal glands, challenging common assumptions about androgen sources.
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March 2021 in “Journal of Experimental Biology and Agricultural Sciences” This study observed that consuming flaxseeds significantly reduced serum free testosterone and improved insulin levels among young women with PCOS, suggesting a promising alternative to conventional treatments.
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July 2019 in “The journal of applied laboratory medicine” This review analyzes 873 cases of female hyperandrogenism, primarily attributing it to polycystic ovarian syndrome, and explores sample testing for suspected neoplasms but reports no new clinical findings.
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July 2015 in “AACE clinical case reports” This case report details a postmenopausal woman with hyperandrogenism due to both adrenal adenoma and ovarian hyperthecosis, highlighting the effectiveness of hormonal suppression and venous sampling for diagnosis.
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May 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)” This study found that increased PSA levels in women with hyperandrogenism may serve as a diagnostic marker, comparable to free testosterone levels.
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August 2012 in “Journal der Deutschen Dermatologischen Gesellschaft” A woman's hyperandrogenism was caused by a genetic mutation leading to non-classic adrenogenital syndrome.
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October 2010 in “Cambridge University Press eBooks” This review discusses strategies for managing dermatological symptoms of hyperandrogenism in PCOS by reducing androgen levels and actions, and reports no new clinical results.
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October 2010 in “Cambridge University Press eBooks” This article reviews the diagnosis of hyperandrogenism in PCOS, discussing its clinical and biochemical components, but reports no new clinical results.
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January 1996 in “Gynecological endocrinology” This article describes a case of severe hyperandrogenism in a 35-year-old woman where high-resolution imaging ruled out tumors, and treatment with cyproterone acetate normalized testosterone levels.
November 2025 in “Clinical Endocrinology” This analysis reports no significant differences between spironolactone and metformin for managing PCOS, noting spironolactone remains a potential off-label option for patients unable to use hormonal contraceptives, but larger studies are necessary to confirm its efficacy.
This study reports that their population showed significant prevalence of vitamin D deficiency, but the impact of supplementation on pregnancy rates remains unclear and requires more research.
April 2024 in “Women s Health Reports” This study explored the clinical and biochemical hyperandrogenic status in adolescents with irregular menses to identify significant indicators of potential metabolic problems linked to PCOS.
Hyperandrogenism is diagnosed using clinical signs, lab tests, and imaging.
September 2021 in “GLOBAL JOURNAL FOR RESEARCH ANALYSIS” This study found that combined hormonal contraceptives containing ethenyl estradiol and cyproterone acetate improved acne, hirsutism, menstrual irregularity, and dysmenorrhea in patients with polycystic ovarian syndrome, with most participants showing significant symptom improvement after 6 to 12 months.
June 2003 in “Obstetrical & Gynecological Survey” Hair loss in women can be treated with hormone therapy.
May 2026 in “Research Square” In this study of women aged 18-45 from an endocrine referral group, researchers found that while clinical hirsutism severity is independently associated with biochemical hyperandrogenism, the relationship is modest and suggests different biological aspects are at play.
In this review, the authors discuss various skin conditions linked to hyperandrogenism, such as acne and alopecia, with a focus on androgen-targeted therapies, suggesting these are generally more effective than non-androgen-targeted options.
April 2026 in “Russian Journal of Skin and Venereal Diseases” This review reports that hyperandrogenic conditions in women, which affect skin and overall well-being, lack dedicated treatment guidelines, presenting challenges in standardizing care.
March 2026 in “JCEM Case Reports” In this case report, a 71-year-old woman with severe hyperandrogenism and virilization revealed a bilateral ovarian steroid cell tumor, confirmed after adnexectomy, resulting in normalized testosterone levels and improved hirsutism post-surgery.
February 2026 in “World Journal of Interdisciplinary Innovation Sciences” This systematic review found that cinnamon supplementation may modestly improve insulin sensitivity and potentially reduce hyperandrogenism in women with PCOS, but stresses the need for large-scale clinical trials.
January 2026 in “Frontiers in Oncology” This case report highlights that in postmenopausal women with severe hyperandrogenism, thorough adrenal and pelvic evaluations, hormonal profiling, and permanent pathology are essential for accurate diagnosis and management of androgen-secreting tumors, such as AGCTs, to prevent misdiagnosis and ensure effective treatment.
October 2025 in “Indian Journal of Physiology and Pharmacology” This case study suggests a potential connection between insulin resistance-induced diabetes and the development of migraine symptoms in a patient with HAIR-AN syndrome, highlighting the importance of early diagnosis and a multifaceted treatment approach.
October 2025 in “Journal of Bahria University Medical and Dental College” In this study, among women with polycystic ovary syndrome, free testosterone was most frequently elevated, highlighting its importance in biochemical assessment and suggesting the need for age-related interpretation of DHEAS levels.
September 2025 in “Reproductive health of woman” This study found that in women with polycystic ovary syndrome, taking metformin for three months significantly reduced serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone, suggesting a beneficial effect on managing hyperandrogenism.
June 2025 in “General medicine and Clinical Practice” This study found that a lifestyle modification program significantly improved androgenic alopecia, acne vulgaris, and hirsutism levels in infertile overweight and obese women, with 36.2% achieving pregnancy post-intervention compared to none before, suggesting enhanced fertility and reduced hyperandrogenism.
March 2025 in “Journal of Pediatric Endocrinology and Metabolism” This study found that total testosterone, DHEA-S, and free androgen index may help distinguish menstrual irregularities from increased risk of polycystic ovary syndrome in adolescents.
January 2025 in “ANNALS OF PAKISTAN MEDICAL & ALLIED PROFESSIONALS” This study found that insulin resistance is common among Pakistani women with PCOS and is independently associated with increased hyperandrogenism, as indicated by correlations with testosterone levels and other androgenic measures.
September 2024 in “Brazilian Journal of Case Reports” In this case study, a 62-year-old woman with severe hyperandrogenism underwent a clomiphene test, which suggested an ovarian origin for her condition, leading to the discovery of a Leydig cell tumor after a bilateral oophorectomy.
August 2024 in “Archives of Women s Mental Health” This study found that women with PCOS exhibited higher levels of depression, tension induction, and impaired stress coping strategies compared to healthy controls, with these psychological issues correlating with hyperandrogenism but not with central obesity or insulin resistance.