Diagnosis and Therapy of Hyperandrogenism

June 1997 in “ Baillière's clinical obstetrics and gynaecology ”

Randall B. Barnes

hyperandrogenism hirsutism polycystic ovary syndrome PCOS flutamide spironolactone gonadotropin-releasing hormone agonists weight loss laparoscopic ovarian electrocautery laser vaporization clomiphene citrate PCOS GnRH agonists weight loss ovarian drilling clomid

TLDR Most women with too much androgens have PCOS, which can be managed with birth control pills, medication for hair growth, and fertility treatments, and losing weight helps too.

The document reviewed various treatments for hyperandrogenism, particularly focusing on hirsutism and polycystic ovary syndrome (PCOS). Studies compared the efficacy of different medications such as flutamide, spironolactone, and gonadotropin-releasing hormone agonists. Flutamide and spironolactone were found to be effective in reducing hirsutism. Weight loss was also noted to correct hormonal imbalances in obese, hyperandrogenic women. Additionally, laparoscopic ovarian electrocautery and laser vaporization improved pregnancy rates in clomiphene citrate-resistant PCOS patients. The document highlighted the importance of individualized treatment plans for managing hyperandrogenism.

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17 / 17 results

research Electrolysis: Observations from 13 Years and 140,000 Hours of Experience

132 citations , October 1995 in “Journal of the American Academy of Dermatology”

Electrolysis is effective for permanent hair removal, but technique is key to avoid scarring, and sometimes hormonal treatment is needed for women with hirsutism.

research Polycystic Ovary Syndrome: Clinical and Biochemical Features

1947 citations , September 1995 in “New England journal of medicine/The New England journal of medicine”

PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.

research Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism

70 citations , August 1995 in “Fertility and Sterility”

Finasteride reduces hairiness and androgen levels in women with unexplained excessive hair growth.

research A Prospective Randomized Trial Comparing Finasteride to Spironolactone in the Treatment of Hirsute Women

34 citations , January 1995 in “The Journal of Clinical Endocrinology and Metabolism”

research Treatment of Hirsutism with Flutamide and a Low-Dosage Oral Contraceptive in Polycystic Ovarian Disease Patients

20 citations , December 1994 in “Fertility and sterility”

Flutamide combined with a low-dose birth control pill effectively reduces excessive hair growth in women with polycystic ovarian disease.

research Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism

17 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Effects of Finasteride, a 5 Alpha-Reductase Inhibitor, on Circulating Androgens and Gonadotropin Secretion in Hirsute Women

21 citations , September 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research A Prospective Study of the Prevalence of Clear-Cut Endocrine Disorders and Polycystic Ovaries in 350 Patients Presenting with Hirsutism or Androgenic Alopecia

135 citations , August 1994 in “Clinical Endocrinology”

Most women with hirsutism or androgenic alopecia had polycystic ovaries, especially if they had irregular periods.

research Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist and Estrogen Replacement Therapy

19 citations , March 1994 in “Fertility and sterility”

The combination therapy reduced hirsutism in women with PCOD and was well-tolerated.

research Comparison of Flutamide and Spironolactone in the Treatment of Hirsutism: A Randomized Controlled Trial

165 citations , February 1994 in “Fertility and Sterility”

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

research Incidence of Liver Toxicity Associated with the Use of Flutamide in Prostate Cancer Patients

116 citations , May 1992 in “The American Journal of Medicine”

Flutamide rarely causes liver toxicity in prostate cancer patients.

research Comparison of Sequential Cyproterone Acetate/Estrogen Versus Spironolactone/Oral Contraceptive in the Treatment of Hirsutism

68 citations , May 1991 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Both cyproterone acetate and spironolactone effectively reduce hair growth in women with hirsutism.

research Treatment of Hirsutism with the Pure Antiandrogen Flutamide

130 citations , September 1990 in “Journal of the American Academy of Dermatology”

Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.

research Treatment of Hirsutism with a Gonadotropin-Releasing Hormone Agonist (Nafarelin)

77 citations , October 1986 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Nafarelin may effectively treat excessive hair growth in women by reducing certain hormone levels.

research The Effects of Two Doses of Spironolactone on Serum Androgens and Anagen Hair in Hirsute Women

142 citations , February 1985 in “Fertility and sterility”

Spironolactone reduced hair thickness and some testosterone levels in women with excessive hair growth.

research Treatment of Hirsutism With Spironolactone

183 citations , March 1982 in “JAMA”

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

research Use of Cyproterone Acetate in the Treatment of Acne, Hirsutism, and Virilism

232 citations , June 1975 in “Journal of Steroid Biochemistry”

Cyproterone acetate is effective for acne but less so for hirsutism and alopecia, with some side effects and quick menstrual cycle recovery after treatment.

5 / 5 results

research Diagnosis of Hyperandrogenism: Clinical Criteria

85 citations , June 2006 in “Best Practice & Research Clinical Endocrinology & Metabolism”

The document concludes that hirsutism is the main sign for diagnosing hyperandrogenism, which requires a detailed patient history and physical exam.

research Spironolactone Therapeutic Effect in the Hyperandrogenism Syndrome

1 citations , April 1993 in “Problemy e̊ndokrinologii”