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This review examines the design strategies for creating conductive hydrogels with adjustable properties for various biomedical applications, highlighting their potential for supporting cell growth, wound healing, drug delivery, tissue regeneration, and biosensing.

This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.

This study reported that a composite hydrogel made with Chlorella-derived extracellular polysaccharide–selenium nanoparticles showed strong antibacterial and anti-inflammatory effects in vitro and significantly accelerated wound healing in vivo, offering potential for managing infected wounds and monitoring healing progression.

This study found that HAMA hydrogels promote faster healing of skin wounds in mice by enhancing the accumulation of anti-inflammatory macrophages and increasing type III collagen in the local wound environment.

This study found that a silver ion cross-linked thiolated protein hydrogel, O3G7, significantly enhanced acute wound healing in mice by increasing collagen content, neovascularization, and reducing inflammation markers compared to a control group.

In this study, the researchers developed a living microecological hydrogel containing Chlorella and Bacillus subtilis that showed potential in promoting the healing of infected diabetic wounds by providing continuous oxygen delivery and anti-infective properties.

This research highlights a hydrogel system that could significantly improve diabetic wound healing by releasing ibuprofen to both suppress inflammation and promote tissue regeneration, indicating a strong potential for future clinical use.

The hydrogel is safe, reduces oxidation, and helps heal wounds effectively.

This review details various components used in hydrogel composites for treating chronic diabetic ulcers and highlights potential future materials but reports no new empirical findings.

This study introduced a rapid rehydration approach for creating customizable, multifunctional hydrogel sensors, enabling precise detection of surface deformations and easy integration of layers, highlighting its potential for standardized and adaptable manufacturing of wearable devices.

This study reports that beta-glucan hybrid hydrogels, reinforced with laponite nanoclay, showed promising results in rat models for managing hemorrhage and diabetic wound healing by enhancing hemostasis, reducing inflammation, and promoting faster wound closure and tissue regeneration.

This study demonstrated that an aloe polysaccharide-collagen wound dressing improved wound healing by enhancing angiogenesis and reducing inflammation in vivo.

This study found that using composite alginate hydrogels containing Aloe vera, CMC, and tragacanth can improve the encapsulation efficiency and protect pumpkin seed protein hydrolysates from degradation during simulated gastrointestinal digestion, potentially increasing their applicability as functional food components.

This study developed keratin-based hydrogels with improved water solubility and tunable properties, demonstrating excellent cytocompatibility, suggesting potential for biomedical applications.

This study found that formulation factors like pH, viscosity, and chemical enhancers can significantly influence intrafollicular hydrocortisone permeation in vitro, with higher pH and enhancers reducing follicular contribution.

This review summarizes numerous studies on adhesive hydrogels with natural antibacterial agents for wound dressings, highlighting their potential as effective treatments with strong antibacterial properties, biocompatibility, and mechanical performance, while minimizing reliance on antibiotics.

This study found that the Nap-F3K-CA hydrogel, when used on burn wounds, demonstrated effective antibacterial and anti-inflammatory properties, promoting accelerated skin repair, decreased wound infections, and improved healing processes, highlighting its potential as a clinical burn wound dressing.

In this study, a hydrogel with anti-inflammatory, antibacterial, antioxidant, and wound tissue adhesion properties was developed, showing significant potential for wound healing and suggesting it could offer a new and effective treatment option in clinical settings.

This review outlines the design and engineering of multifunctional hydrogels, emphasizing their evolving biomedical applications, notably in controlled drug delivery, tissue support, and disease management, and discusses their potential for clinical translation.

In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.

This study reported that a decellularized porcine amniotic membrane hydrogel can alleviate inflammation and promote tissue repair in a UVB-induced skin inflammation model, suggesting its potential as a regenerative treatment for photodamage-associated skin injuries.

This review discusses the growing importance of hydrogel scaffolds in skin wound healing, highlighting their unique properties and recent advancements in their use for treating difficult tissue damage, particularly within tissue engineering.

This review discusses the potential of hydrogel-based interventions for radiation-induced skin injury, providing no new clinical results but highlighting their synergistic mechanisms and promise in improving treatment strategies.

This review discusses recent advancements in the development and use of polymer-based nanohydrogels for topical drug delivery, noting their potential to enhance drug loading, release control, and skin penetration for treating dermatological conditions.

This study found that a double-crosslinked hydrogel using GelMA and sulfhydrylated chitosan showed promising results in healing full-thickness skin wounds in rats by accelerating tissue repair and promoting collagen and blood vessel formation.

This review assesses the benefits and limitations of various supramolecular hydrogels, including polymeric and peptide-based types, for wound healing, but reports no new clinical results.

The hydrogel helps heal diabetic wounds by combining antibacterial, antioxidant, and immune-boosting effects.

This study found that an injectable hydrogel dressing with silver nanoparticles showed promise in healing MRSA-infected wounds by reducing inflammation, supporting tissue regeneration, and maintaining prolonged antibacterial activity, highlighting its potential as an effective treatment strategy.

In diabetic mice, this study reported that the multifunctional hydrogel CPGel achieved complete wound closure in 21 days, showing promise in improving chronic wound healing through antibacterial, antioxidative, and tissue regeneration properties.